The N-terminal region of RECQL4 lacking the helicase domain is both essential and sufficient for the viability of vertebrate cells. Role of the N-terminal region of RECQL4 in cells.
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RECQL4 in genomic instability and agingThe DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formationRelative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell linesRecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cellsImpaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction.Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.Rare copy number variants observed in hereditary breast cancer cases disrupt genes in estrogen signaling and TP53 tumor suppression networkDrosophila RecQ4 is directly involved in both DNA replication and the response to UV damage in S2 cells.The intrinsically disordered amino-terminal region of human RecQL4: multiple DNA-binding domains confer annealing, strand exchange and G4 DNA binding.The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patientsHuman RecQ helicases in DNA repair, recombination, and replication.The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability.Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells.Structural and biochemical characterization of an RNA/DNA binding motif in the N-terminal domain of RecQ4 helicases.CDK phosphorylation of SLD-2 is required for replication initiation and germline development in C. elegans.Evolutionary conservation of the CDK targets in eukaryotic DNA replication initiation.The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism.Activation of p38 MAP kinase and stress signalling in fibroblasts from the progeroid Rothmund-Thomson syndrome.Rothmund-Thomson Syndrome: Insights from New Patients on the Genetic Variability Underpinning Clinical Presentation and Cancer Outcome.
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P2860
The N-terminal region of RECQL4 lacking the helicase domain is both essential and sufficient for the viability of vertebrate cells. Role of the N-terminal region of RECQL4 in cells.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
The N-terminal region of RECQL ...... nal region of RECQL4 in cells.
@en
The N-terminal region of RECQL ...... nal region of RECQL4 in cells.
@nl
type
label
The N-terminal region of RECQL ...... nal region of RECQL4 in cells.
@en
The N-terminal region of RECQL ...... nal region of RECQL4 in cells.
@nl
prefLabel
The N-terminal region of RECQL ...... nal region of RECQL4 in cells.
@en
The N-terminal region of RECQL ...... nal region of RECQL4 in cells.
@nl
P2093
P1476
The N-terminal region of RECQL ...... nal region of RECQL4 in cells.
@en
P2093
Akari Yoshimura
Masayuki Seki
Shusuke Tada
Takemi Enomoto
Yoshifumi Hosono
P304
P356
10.1016/J.BBAMCR.2011.01.001
P50
P577
2011-01-20T00:00:00Z