Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.
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Long-Range Regulation of V(D)J RecombinationCTCF: making the right connectionsEpigenetic control of immunityEμ and 3'RR IgH enhancers show hierarchic unilateral dependence in mature B-cells.YY1 and CTCF orchestrate a 3D chromatin looping switch during early neural lineage commitmentCTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation3D trajectories adopted by coding and regulatory DNA elements: first-passage times for genomic interactions.A major deletion in the Vκ-Jκ intervening region results in hyperelevated transcription of proximal Vκ genes and a severely restricted repertoire.Role of YY1 in long-range chromosomal interactions regulating Th2 cytokine expressionDirected targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins.Insertion of an imprinted insulator into the IgH locus reveals developmentally regulated, transcription-dependent control of V(D)J recombination.Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.Interpreting 4C-Seq data: how far can we go?Complete cis Exclusion upon Duplication of the Eμ Enhancer at the Immunoglobulin Heavy Chain Locus.The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth.Domain-Specific and Stage-Intrinsic Changes in Tcrb Conformation during Thymocyte Development.CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability.YY1 Is Required for Germinal Center B Cell Development.A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformationDevelopmental Switch in the Transcriptional Activity of a Long-Range Regulatory Element.A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRδ and TCRα repertoiresDeciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory regionYin Yang 1 Promotes Thymocyte Survival by Downregulating p53.Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombinationThe Ties that Bind (the Igh Locus)Two Mutually Exclusive Local Chromatin States Drive Efficient V(D)J RecombinationExtremely Long-Range Chromatin Loops Link Topological Domains to Facilitate a Diverse Antibody Repertoire.Genomic Architecture may Influence Recurrent Chromosomal Translocation Frequency in the Igh Locus.Function of YY1 in Long-Distance DNA Interactions.Epigenetic Regulation of Individual Modules of the immunoglobulin heavy chain locus 3' Regulatory Region.YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction.Hierarchical role for transcription factors and chromatin structure in genome organization along adipogenesis.Exploring the mechanisms of genome-wide long-range interactions: interpreting chromosome organization.Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell developmentTcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.The IgH 3' regulatory region influences lymphomagenesis in Igλ-Myc miceNuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci.Rapid movement and transcriptional re-localization of human cohesin on DNA
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P2860
Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Flexible long-range loops in t ...... a diverse antibody repertoire.
@en
Flexible long-range loops in t ...... a diverse antibody repertoire.
@nl
type
label
Flexible long-range loops in t ...... a diverse antibody repertoire.
@en
Flexible long-range loops in t ...... a diverse antibody repertoire.
@nl
prefLabel
Flexible long-range loops in t ...... a diverse antibody repertoire.
@en
Flexible long-range loops in t ...... a diverse antibody repertoire.
@nl
P2093
P2860
P50
P1433
P1476
Flexible long-range loops in t ...... a diverse antibody repertoire.
@en
P2093
Anja Ebert
Chunguang Guo
Frederick W Alt
Hye Suk Yoon
Ido M Tamir
Jasna Medvedovic
Maria Novatchkova
Sjoerd J B Holwerda
Wouter de Laat
P2860
P304
P356
10.1016/J.IMMUNI.2013.08.011
P407
P577
2013-08-01T00:00:00Z