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Chemical modification of capuramycins to enhance antibacterial activity

Chemical modification of capuramycins to enhance antibacterial activity

http://www.wikidata.org/entity/Q39615555

about

Structural insights into inhibition of lipid I production in bacterial cell wall synthesis.Treatment of Clostridium difficile infection using SQ641, a capuramycin analogue, increases post-treatment survival and improves clinical measures of disease in a murine model.Identification of SQ609 as a lead compound from a library of dipiperidines.Discovery of a capuramycin analog that kills nonreplicating Mycobacterium tuberculosis and its synergistic effects with translocase I inhibitors Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors.Therapeutic efficacy of SQ641-NE against Mycobacterium tuberculosis.Improved synthesis of capuramycin and its analogues.Recent derivatives from smaller classes of fermentation-derived antibacterials.Antimycobacterial drugs currently in Phase II clinical trials and preclinical phase for tuberculosis treatment.The anti-tuberculosis agents under development and the challenges ahead.

P2860

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P2860

Chemical modification of capuramycins to enhance antibacterial activity

http://www.wikidata.org/entity/Q39615555

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

2010年论文

@zh

2010年论文

@zh-cn

name

Chemical modification of capuramycins to enhance antibacterial activity

@en

Chemical modification of capuramycins to enhance antibacterial activity.

@nl

type

label

Chemical modification of capuramycins to enhance antibacterial activity

@en

Chemical modification of capuramycins to enhance antibacterial activity.

@nl

prefLabel

Chemical modification of capuramycins to enhance antibacterial activity

@en

Chemical modification of capuramycins to enhance antibacterial activity.

@nl

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P1433

Journal of Antimicrobial Chemotherapy

P1476

Chemical modification of capuramycins to enhance antibacterial activity

@en

P2093

Carol A Nacy

http://www.w3.org/2001/XMLSchema#string

Elena Bogatcheva

http://www.w3.org/2001/XMLSchema#string

Leo Einck

http://www.w3.org/2001/XMLSchema#string

Marina Protopopova

http://www.w3.org/2001/XMLSchema#string

Tia Dubuisson

http://www.w3.org/2001/XMLSchema#string

Venkata M Reddy

http://www.w3.org/2001/XMLSchema#string

P2860

Multidrug resistance in bacteria

Synthesis of the nucleoside moiety of liposidomycins: elucidation of the pharmacophore of this family of MraY inhibitors.

Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196.

In vitro interactions between new antitubercular drug candidates SQ109 and TMC207.

Assessment of immunity to mycobacterial infection with luciferase reporter constructs.

Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria

Recent advances in antimicrobial nucleoside antibiotics targeting cell wall biosynthesis.

Structure and function of efflux pumps that confer resistance to drugs

Efflux-mediated antimicrobial resistance.

Role of mycobacterial efflux transporters in drug resistance: an unresolved question.

P304

578-587

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scholarly article

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10.1093/JAC/DKQ495

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3

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66

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2010-12-23T00:00:00Z

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49709765

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21186194

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3037154

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