Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis.
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Regulatory mechanisms of phosphatase of regenerating liver (PRL)-3Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasisTargeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer.MicroRNA-192 suppresses liver metastasis of colon cancer.Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent mannerTherapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancerPRL-3 promotes telomere deprotection and chromosomal instability.VEGF promotes the transcription of the human PRL-3 gene in HUVEC through transcription factor MEF2CA role of autophagy in PTP4A3-driven cancer progression.Dose dependent activation of retinoic acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma.Tissue-specific alterations of PRL-1 and PRL-2 expression in cancerDown-regulation of programmed cell death 4 leads to epithelial to mesenchymal transition and promotes metastasis in mice.Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition.Molecular mechanisms of the PRL phosphatases.The regulatory roles of phosphatases in cancer.Molecular targets and pathways involved in liver metastasis of colorectal cancer.Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration.Expression of miR-126 suppresses migration and invasion of colon cancer cells by targeting CXCR4.Genomic gain of the PRL-3 gene may represent poor prognosis of primary colorectal cancer, and associate with liver metastasis.Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice.Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications.PRL‑3 increases the aggressive phenotype of prostate cancer cells in vitro and its expression correlates with high-grade prostate tumors in patients.Expression of phosphatase of regenerating liver (PRL)-3, is independently associated with biochemical failure, clinical failure and death in prostate cancer.R-Spondin1/LGR5 Activates TGFβ Signaling and Suppresses Colon Cancer Metastasis.TGFβ and IGF1R signaling activate protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells.PRL-3 is a potential glioblastoma prognostic marker and promotes glioblastoma progression by enhancing MMP7 through the ERK and JNK pathways.A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase.A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion
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P2860
Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis.
@en
Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis.
@nl
type
label
Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis.
@en
Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis.
@nl
prefLabel
Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis.
@en
Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis.
@nl
P2093
P2860
P1433
P1476
Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis.
@en
P2093
Ashwani Rajput
Gregory S Taylor
Liying Geng
Melanie Ongchin
Xiao-Qiong Liu
Yanjun Jiang
P2860
P304
P356
10.1158/0008-5472.CAN-10-1487
P407
P577
2010-11-16T00:00:00Z