about
Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylationA Single Kinase Generates the Majority of the Secreted PhosphoproteomeSecreted protein kinasesThe ATP-binding site of protein kinase CK2 holds a positive electrostatic area and conserved water moleculesCoumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationshipsQuinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1AUnprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancerStructural determinants of protein kinase CK2 regulation by autoinhibitory polymerizationInhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insightCell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potentialUnderstanding protein kinase CK2 mis-regulation upon F508del CFTR expressionEffects of the CK2 inhibitors CX-4945 and CX-5011 on drug-resistant cellsGolgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9The SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs.4-Fluoroproline derivative peptides: effect on PPII conformation and SH3 affinity.Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity.Chemical derivatization of phosphoserine and phosphothreonine containing peptides to increase sensitivity for MALDI-based analysis and for selectivity of MS/MS analysis.Sic1 is phosphorylated by CK2 on Ser201 in budding yeast cells.The selectivity of inhibitors of protein kinase CK2: an update.Inhibition of protein kinase CK2 suppresses angiogenesis and hematopoietic stem cell recruitment to retinal neovascularization sites.Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization.Cystic fibrosis transmembrane regulator fragments with the Phe508 deletion exert a dual allosteric control over the master kinase CK2.CK1δ kinase activity is modulated by Chk1-mediated phosphorylation.Detection of phospho-sites generated by protein kinase CK2 in CFTR: mechanistic aspects of Thr1471 phosphorylationSynthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions.Identification of the PLK2-dependent phosphopeptidome by quantitative proteomics [corrected].The first armadillo repeat is involved in the recognition and regulation of beta-catenin phosphorylation by protein kinase CK1Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cellsTools to discriminate between targets of CK2 vs PLK2/PLK3 acidophilic kinases.Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutationThe Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation.Features and potentials of ATP-site directed CK2 inhibitors.CFTR mutations altering CFTR fragmentation.A structural insight into CK2 inhibition.Protein kinase CK2 as a druggable target.Addiction to protein kinase CK2: a common denominator of diverse cancer cells?Casein kinase 2: an 'eminence grise' in cellular regulation?Protein kinase CK2 inhibitors: a patent review.
P50
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P50
description
hulumtues
@sq
researcher
@en
ricercatore
@it
wetenschapper
@nl
հետազոտող
@hy
name
Lorenzo A Pinna
@ast
Lorenzo A Pinna
@en
Lorenzo A Pinna
@es
Lorenzo A Pinna
@nl
Lorenzo A Pinna
@sl
type
label
Lorenzo A Pinna
@ast
Lorenzo A Pinna
@en
Lorenzo A Pinna
@es
Lorenzo A Pinna
@nl
Lorenzo A Pinna
@sl
prefLabel
Lorenzo A Pinna
@ast
Lorenzo A Pinna
@en
Lorenzo A Pinna
@es
Lorenzo A Pinna
@nl
Lorenzo A Pinna
@sl
P214
P244
P106
P1343
P21
P213
0000 0000 2032 1005
P214
P244
P31
P3762
P496
0000-0002-8856-4956
P569
1939-01-01T00:00:00Z
P735
P7859
lccn-n78079695