The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells. - Wikidata - awgldk - TriplyDB

The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells.

The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells.

http://www.wikidata.org/entity/Q39644498

about

Modulation of Autophagy by Sorafenib: Effects on Treatment Response Melanoma: new insights and new therapies The FNTB promoter polymorphism rs11623866 as a potential predictive biomarker for lonafarnib treatment of ovarian cancer patients.Expression of drug targets in patients treated with sorafenib, carboplatin and paclitaxel Manumycin induces apoptosis in prostate cancer cells Sorafenib: complexities of Raf-dependent and Raf-independent signaling are now unveiled.Small molecule inhibitors in acute myeloid leukemia: from the bench to the clinic Prenylation inhibition-induced cell death in melanoma: reduced sensitivity in BRAF mutant/PTEN wild-type melanoma cells Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and α-Mangostin.Targeting drivers of melanoma with synthetic small molecules and phytochemicals.Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function.Molecular targeted therapies in metastatic melanoma.Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines.Combination therapy with zoledronic acid and cetuximab effectively suppresses growth of colorectal cancer cells regardless of KRAS status.Predicting Drug Combination Index and Simulating the Network-Regulation Dynamics by Mathematical Modeling of Drug-Targeted EGFR-ERK Signaling Pathway.NRAS mutant melanoma: biological behavior and future strategies for therapeutic management.Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.Lonafarnib for cancer and progeria.Targeting MAPK pathway in melanoma therapy.Melanoma mutagenesis and aberrant cell signaling.Non-BRAF-targeted therapy, immunotherapy, and combination therapy for melanoma.Mechanisms of tumour vascularization in cutaneous malignant melanoma: clinical implications.Towards combinatorial targeted therapy in melanoma: from pre-clinical evidence to clinical application (review).NRAS-mutant melanoma: current challenges and future prospect Potential therapeutic targets of epithelial-mesenchymal transition in melanoma.FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis.A 3D Organotypic Melanoma Spheroid Skin Model.

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P2860

The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells.

http://www.wikidata.org/entity/Q39644498

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

@zh-tw

2010年论文

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2010年论文

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2010年论文

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name

The farnesyl transferase inhib ...... d apoptosis in melanoma cells.

@en

The farnesyl transferase inhib ...... d apoptosis in melanoma cells.

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type

label

The farnesyl transferase inhib ...... d apoptosis in melanoma cells.

@en

The farnesyl transferase inhib ...... d apoptosis in melanoma cells.

@nl

prefLabel

The farnesyl transferase inhib ...... d apoptosis in melanoma cells.

@en

The farnesyl transferase inhib ...... d apoptosis in melanoma cells.

@nl

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Journal of Investigative Dermatology

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The farnesyl transferase inhib ...... d apoptosis in melanoma cells.

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P2093

Alexander Berger

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Birgit Schittek

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Claus Garbe

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Dagmar Kulms

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Daniela Beck

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Evelyn Maczey

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Friedegund Meier

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Heike Niessner

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Jeannette Gogel

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Konstantinos Lasithiotakis

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P2888

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468-479

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scholarly article

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10.1038/JID.2010.297

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2

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131

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Dirk Schadendorf

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2010-10-14T00:00:00Z

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232770845

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