Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition - Wikidata - awgldk - TriplyDB

Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition

Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition

http://www.wikidata.org/entity/Q39644973

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Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress Spindle assembly checkpoint acquisition at the mid-blastula transition Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation Roles of Chk1 in cell biology and cancer therapy The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons Titration of four replication factors is essential for the Xenopus laevis midblastula transition Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding Wee1 kinase alters cyclin E/Cdk2 and promotes apoptosis during the early embryonic development of Xenopus laevis Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases.Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs.Cdc25 and the importance of G2 control: insights from developmental biology.Remodeling of the metabolome during early frog development TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1).Grp/DChk1 is required for G2-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensable Tight Chk1 Levels Control Replication Cluster Activation in Xenopus.Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis.From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transition.Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine.Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus.Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells New opportunities in chemosensitization and radiosensitization: modulating the DNA-damage response.Zebrafish cdc25a is expressed during early development and limiting for post-blastoderm cell cycle progression.Cytokine-driven cell cycling is mediated through Cdc25A.Phase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias.Suppressors of the cdc-25.1(gf)-associated intestinal hyperplasia reveal important maternal roles for prp-8 and a subset of splicing factors in C. elegans.The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF beta-TrCP-dependent degradation for cell cycle arrest.Control of DNA replication by the nucleus/cytoplasm ratio in Xenopus.A quantitative model of the effect of unreplicated DNA on cell cycle progression in frog egg extracts.DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress.Restricted expression of cdc25a in the tailbud is essential for formation of the zebrafish posterior body Genetic variation and DNA replication timing, or why is there late replicating DNA?CRL Ubiquitin Ligases and DNA Damage Response.Emerging mechanisms regulating mitotic synchrony during animal embryogenesis.

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P2860

Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition

http://www.wikidata.org/entity/Q39644973

description

2002 nî lūn-bûn

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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2002年论文

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2002年论文

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name

Chk1 is activated transiently ...... Xenopus midblastula transition

@en

Chk1 is activated transiently ...... enopus midblastula transition.

@nl

type

label

Chk1 is activated transiently ...... Xenopus midblastula transition

@en

Chk1 is activated transiently ...... enopus midblastula transition.

@nl

prefLabel

Chk1 is activated transiently ...... Xenopus midblastula transition

@en

Chk1 is activated transiently ...... enopus midblastula transition.

@nl

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The EMBO Journal

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Chk1 is activated transiently ...... Xenopus midblastula transition

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P2093

Katsuhiro Uto

http://www.w3.org/2001/XMLSchema#string

Ken Shimuta

http://www.w3.org/2001/XMLSchema#string

Kenji Okazaki

http://www.w3.org/2001/XMLSchema#string

Nobushige Nakajo

http://www.w3.org/2001/XMLSchema#string

Noriyuki Sagata

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Yoshimasa Hayano

http://www.w3.org/2001/XMLSchema#string

P2860

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation

The DNA damage response: putting checkpoints in perspective

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

Cdc25 protein phosphatases in cell proliferation

DNA-replication checkpoint control at the Drosophila midblastula transition

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding

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3694-3703

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10.1093/EMBOJ/CDF357

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21

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11267147

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12110582

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125399

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