Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1.
about
The SLCO (former SLC21) superfamily of transporters.Scoparone potentiates transactivation of the bile salt export pump gene and this effect is enhanced by cytochrome P450 metabolism but abolished by a PKC inhibitor.The farnesoid X receptor -1G>T polymorphism influences the lipid response to rosuvastatin.Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Organic anion-transporting polypeptides.Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver.Effect of drug transporter pharmacogenetics on cholestasis.Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility.The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors.Role of farnesoid X receptor in cholestasis.Interaction potential of the endothelin-A receptor antagonist atrasentan with drug transporters and drug-metabolising enzymes assessed in vitro.Effect of erythropoietin on hepatic cytochrome P450 expression and function in an adenine-fed rat model of chronic kidney disease.Association of liver stiffness with hepatic expression of pharmacokinetically important genes in alcoholic liver disease.Effect of posaconazole on the pharmacokinetics of simvastatin and midazolam in healthy volunteers.The pregnane X receptor agonist St John's Wort has no effects on the pharmacokinetics and pharmacodynamics of repaglinide.Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions.Update on FXR Biology: Promising Therapeutic Target?
P2860
Q34333710-2CACCBEF-30C9-433A-B768-0DB996BDC423Q35564302-3261E909-CBE0-4BDE-AFCC-1105327B1555Q36020304-14006765-B9AC-4877-A706-EDC2580425B8Q36998199-9CC6540D-44F9-49BC-BE53-FED183431413Q37121662-3945176F-F40A-4DE8-9698-EE6E5C240772Q37718185-E8C747AF-2F61-4082-B342-5BD26D8D41CAQ38074991-7D47BDF9-AB60-45BB-BDC6-8886140A25BAQ38254730-BD572E5E-7EA9-431E-9431-1FD1909B5D6AQ38305576-93B72CF6-1D92-4C28-BEF1-67A4D49371AAQ38750759-56E8647E-FB3D-4DB5-AF73-221D2667C69AQ38887864-EDCF3C26-7CCC-488F-9CBF-2DB72012A3F3Q39497283-0256B0F6-B5E9-4F81-B1D5-C911AC8F6804Q42552831-F110797B-065D-4931-B978-56498EE9B859Q43867191-FCB79C23-834A-4D70-8A34-90CDA0F327A1Q48202863-E6264402-9657-4471-B472-2147D4774409Q48809049-63F1A32F-9836-4ED4-BFCE-511C9A26561DQ55046512-8A4F7248-D3ED-4898-AB83-D4C7D341903DQ57114776-8F4F5746-12A0-4857-B5CF-43D2547FA384
P2860
Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Liver X receptor α and farneso ...... ptional regulators of OATP1B1.
@en
Liver X receptor α and farneso ...... ptional regulators of OATP1B1.
@nl
type
label
Liver X receptor α and farneso ...... ptional regulators of OATP1B1.
@en
Liver X receptor α and farneso ...... ptional regulators of OATP1B1.
@nl
prefLabel
Liver X receptor α and farneso ...... ptional regulators of OATP1B1.
@en
Liver X receptor α and farneso ...... ptional regulators of OATP1B1.
@nl
P2093
P356
P1433
P1476
Liver X receptor α and farneso ...... iptional regulators of OATP1B1
@en
P2093
Amarjit Chaudhry
Erin G Schuetz
Heyo K Kroemer
Kerstin Böttcher
Richard B Kim
P304
P356
10.1002/HEP.23876
P407
P577
2010-11-01T00:00:00Z