Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo. - Wikidata - awgldk - TriplyDB

Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo.

Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo.

http://www.wikidata.org/entity/Q39668353

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Selective overexpression of dopamine D3 receptors in the striatum disrupts motivation but not cognition.Dopamine D₃ receptor alterations in cocaine-dependent humans imaged with [¹¹C](+)PHNO.Further characterization of quinpirole-elicited yawning as a model of dopamine D3 receptor activation in male and female monkeys.Estimating endogenous dopamine levels at D2 and D3 receptors in humans using the agonist radiotracer [(11)C]-(+)-PHNO Parametric Imaging and Test-Retest Variability of ¹¹C-(+)-PHNO Binding to D₂/D₃ Dopamine Receptors in Humans on the High-Resolution Research Tomograph PET Scanner Targeting the dopamine D3 receptor: an overview of drug design strategies.A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [(11)C](+)PHNO Characterization of extrastriatal D2 in vivo specific binding of [¹⁸F](N-methyl)benperidol using PET.Dopamine D3 receptor binding of (18)F-fallypride: Evaluation using in vitro and in vivo PET imaging studies.Dopamine response to psychosocial stress in chronic cannabis users: a PET study with [11C]-+-PHNO.Dopamine D2 and D3 binding in people at clinical high risk for schizophrenia, antipsychotic-naive patients and healthy controls while performing a cognitive task Age-related changes in binding of the D2/3 receptor radioligand [(11)C](+)PHNO in healthy volunteers.Varenicline-Induced Elevation of Dopamine in Smokers: A Preliminary [(11)C]-(+)-PHNO PET Study.Test-retest reproducibility of [11C]-(+)-propyl-hexahydro-naphtho-oxazin positron emission tomography using the bolus plus constant infusion paradigm.Dopamine D3 Receptor Availability Is Associated with Inflexible Decision Making.Deficits in striatal dopamine release in cannabis dependence.Preferential binding to dopamine D3 over D2 receptors by cariprazine in patients with schizophrenia using PET with the D3/D2 receptor ligand [(11)C]-(+)-PHNO Medication discovery for addiction: translating the dopamine D3 receptor hypothesis.Elevation of dopamine induced by cigarette smoking: novel insights from a [11C]-+-PHNO PET study in humans Imaging nicotine- and amphetamine-induced dopamine release in rhesus monkeys with [(11)C]PHNO vs [(11)C]raclopride PET.Exploring the relationship between social attachment and dopamine D2/3 receptor availability in the brains of healthy humans using [11C]-(+)-PHNO.Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography.Rationale in support of the use of selective dopamine D₃ receptor antagonists for the pharmacotherapeutic management of substance use disorders.Dopamine D₃ receptor antagonism--still a therapeutic option for the treatment of schizophrenia.Dopamine D3 receptor antagonists: a patent review (2007 - 2012).The relationship between subcortical brain volume and striatal dopamine D2/3 receptor availability in healthy humans assessed with [(11) C]-raclopride and [(11) C]-(+)-PHNO PET.Association of Stimulant Use With Dopaminergic Alterations in Users of Cocaine, Amphetamine, or Methamphetamine: A Systematic Review and Meta-analysis.The dopamine D3 receptor, a quarter century later.New imaging probes to track cell fate: reporter genes in stem cell research.Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO.Direct and indirect interactions of the dopamine D₃ receptor with glutamate pathways: implications for the treatment of schizophrenia.Brain uptake and distribution of the dopamine D3 /D2 receptor partial agonist [11 C]cariprazine: an in vivo positron emission tomography study in nonhuman primates.Quantitative PET Imaging in Drug Development: Estimation of Target Occupancy.Different effects of chronic THC on the neuroadaptive response of dopamine D2/3 receptor-mediated signaling in roman high- and roman low-avoidance rats.Nigral Stress-Induced Dopamine Release in Clinical High Risk and Antipsychotic-Naïve Schizophrenia.Evaluation of PET Brain Radioligands for Imaging Pancreatic β-Cell Mass: Potential Utility of 11C-PHNO.Surrogate markers for cerebral blood flow correlate with [¹⁸F]-fallypride binding potential at dopamine D(2/3) receptors in human striatum.Regional and source-based patterns of [11C]-(+)-PHNO binding potential reveal concurrent alterations in dopamine D2 and D3 receptor availability in cocaine-use disorder.Amphetamine-Induced Striatal Dopamine Release Measured With an Agonist Radiotracer in Schizophrenia.Determination of receptor occupancy in the presence of mass dose: [11C]GSK189254 PET imaging of histamine H3 receptor occupancy by PF-03654746.

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P2860

Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo.

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Affinity and selectivity of [¹¹C]-

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Affinity and selectivity of [¹ ...... e rhesus monkey brain in vivo.

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Affinity and selectivity of [¹¹C]-

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Affinity and selectivity of [¹ ...... e rhesus monkey brain in vivo.

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Affinity and selectivity of [¹¹C]-

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Affinity and selectivity of [¹ ...... e rhesus monkey brain in vivo.

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Affinity and selectivity of [¹ ...... e rhesus monkey brain in vivo.

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David Weinzimmer

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Eugenii A Rabiner

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Jean-Dominique Gallezot

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John D Beaver

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Krista Fowles

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Marc Laruelle

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Mark Slifstein

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Nabeel Nabulsi

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Richard E Carson

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Roger N Gunn

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P2860

Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N-di-n-propyl-2-aminotetralin

Increased baseline occupancy of D2 receptors by dopamine in schizophrenia

An Algorithm for Least-Squares Estimation of Nonlinear Parameters

Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

Consensus nomenclature for in vivo imaging of reversibly binding radioligands.

The dopamine D2 receptors in high-affinity state and D3 receptors in schizophrenia: a clinical [11C]-(+)-PHNO PET study.

Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist.

Side effects profile in humans of (11)C-(+)-PHNO, a dopamine D(2/3) agonist ligand for PET.

In vivo quantification of regional dopamine-D3 receptor binding potential of (+)-PHNO: Studies in non-human primates and transgenic mice.

Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography.

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489-500

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10.1002/SYN.21535

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6

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66

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Eugenii A. Rabiner

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22213512

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