The synthesis and preclinical evaluation in rhesus monkey of [¹⁸F]MK-6577 and [¹¹C]CMPyPB glycine transporter 1 positron emission tomography radiotracers.
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Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead.Imaging glutamate in schizophrenia: review of findings and implications for drug discovery.Relationship between glycine transporter 1 inhibition as measured with positron emission tomography and changes in cognitive performances in nonhuman primatesGlycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain.Measurement of Bmax and Kd with the glycine transporter 1 radiotracer ¹⁸F-MK6577 using a novel multi-infusion paradigm.Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([11 C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1.Glycine transporter type 1 occupancy by bitopertin: a positron emission tomography study in healthy volunteers.In Vivo Evaluation of (11)C-labeled Three Radioligands for Glycine Transporter 1 in the Mouse BrainMarine Ο-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD.Glycine transporter-1 inhibition promotes striatal axon sprouting via NMDA receptors in dopamine neurons18F-labelled intermediates for radiosynthesis by modular build-up reactions: newer developments.Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1.The relationship between glycine transporter 1 occupancy and the effects of the glycine transporter 1 inhibitor RG1678 or ORG25935 on object retrieval performance in scopolamine impaired rhesus monkey.Characterization of the novel GlyT1 PET tracer [18F]MK-6577 in humans.Comparative evaluation of two glycine transporter 1 radiotracers [11C]GSK931145 and [18F]MK-6577 in baboons.Translational characterization of [11C]GSK931145, a PET ligand for the glycine transporter type 1.
P2860
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P2860
The synthesis and preclinical evaluation in rhesus monkey of [¹⁸F]MK-6577 and [¹¹C]CMPyPB glycine transporter 1 positron emission tomography radiotracers.
description
2011 nî lūn-bûn
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2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
The synthesis and preclinical ...... ssion tomography radiotracers.
@en
The synthesis and preclinical ...... ssion tomography radiotracers.
@nl
type
label
The synthesis and preclinical ...... ssion tomography radiotracers.
@en
The synthesis and preclinical ...... ssion tomography radiotracers.
@nl
prefLabel
The synthesis and preclinical ...... ssion tomography radiotracers.
@en
The synthesis and preclinical ...... ssion tomography radiotracers.
@nl
P2093
P2860
P356
P1433
P1476
The synthesis and preclinical ...... ssion tomography radiotracers.
@en
P2093
Andrew Jennings
Christine Ryan
Cyrille Sur
David Wisnoski
H Donald Burns
Jacquelynn Cook
Kerry Riffel
Leslie Street
Richard Hargreaves
Richard Lewis
P2860
P304
P356
10.1002/SYN.20842
P577
2011-04-01T00:00:00Z