Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway.
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The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolismPulmonary fibrosis in response to environmental cues and molecular targets involved in its pathogenesisRedox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expressionDistinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells.Sphingosine 1-phosphate chemical biologymicroRNA 21: response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells.TGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucomaStimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema.The self-limiting dynamics of TGF-β signaling in silico and in vitro, with negative feedback through PPM1A upregulation.Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphateDihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levelsEnhanced tumor cures after Foscan photodynamic therapy combined with the ceramide analog LCL29. Evidence from mouse squamous cell carcinomas for sphingolipids as biomarkers of treatment response.Identification and characterization of protein phosphatase 2C activation by ceramide.Establishment and characterization of scleroderma fibroblast clonal cell lines by introduction of the hTERT gene.Phospho-control of TGF-beta superfamily signaling.Lipid mediators in the neural cell nucleus: their metabolism, signaling, and association with neurological disorders.Noncanonical transforming growth factor beta signaling in scleroderma fibrosisPost-translational regulation of TGF-β receptor and Smad signaling.Sphingolipid regulation of tissue fibrosisUnravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma.3-Ketosphinganine provokes the accumulation of dihydroshingolipids and induces autophagy in cancer cells.Autocrine transforming growth factor β signaling regulates extracellular signal-regulated kinase 1/2 phosphorylation via modulation of protein phosphatase 2A expression in scleroderma fibroblasts.Loss of expression of protein phosphatase magnesium-dependent 1A during kidney injury promotes fibrotic maladaptive repair.FTY720 ameliorates murine sclerodermatous chronic graft-versus-host disease by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin.Integration of Canonical and Noncanonical Pathways in TLR4 Signaling: Complex Regulation of the Wound Repair Program.TGF-β/SMAD3 Pathway Stimulates Sphingosine-1 Phosphate Receptor 3 Expression: IMPLICATION OF SPHINGOSINE-1 PHOSPHATE RECEPTOR 3 IN LUNG ADENOCARCINOMA PROGRESSION.De novo synthesis of protein phosphatase 1A, magnesium dependent, alpha isoform (PPM1A) during oocyte maturation.Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates.
P2860
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P2860
Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Opposite effects of dihydrosph ...... PTEN/PPM1A-dependent pathway.
@en
Opposite effects of dihydrosph ...... PTEN/PPM1A-dependent pathway.
@nl
type
label
Opposite effects of dihydrosph ...... PTEN/PPM1A-dependent pathway.
@en
Opposite effects of dihydrosph ...... PTEN/PPM1A-dependent pathway.
@nl
prefLabel
Opposite effects of dihydrosph ...... PTEN/PPM1A-dependent pathway.
@en
Opposite effects of dihydrosph ...... PTEN/PPM1A-dependent pathway.
@nl
P2860
P356
P1476
Opposite effects of dihydrosph ...... PTEN/PPM1A-dependent pathway.
@en
P2093
Bagrat Kapanadze
Shizhong Bu
P2860
P304
19593-19602
P356
10.1074/JBC.M802417200
P407
P577
2008-05-15T00:00:00Z