Substitution in the murine nectin1 receptor of a single conserved amino acid at a position distal from the herpes simplex virus gD binding site confers high-affinity binding to gD.
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Cellular localization of nectin-1 and glycoprotein D during herpes simplex virus infectionThe pro-fusion domain of herpes simplex virus glycoprotein D (gD) interacts with the gD N terminus and is displaced by soluble forms of viral receptors.The soluble ectodomain of herpes simplex virus gD contains a membrane-proximal pro-fusion domain and suffices to mediate virus entryThe domains of glycoprotein D required to block apoptosis induced by herpes simplex virus 1 are largely distinct from those involved in cell-cell fusion and binding to nectin1Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxicity.Entry of herpes simplex virus mediated by chimeric forms of nectin1 retargeted to endosomes or to lipid rafts occurs through acidic endosomes.Heptad repeat 2 in herpes simplex virus 1 gH interacts with heptad repeat 1 and is critical for virus entry and fusion.A heptad repeat in herpes simplex virus 1 gH, located downstream of the alpha-helix with attributes of a fusion peptide, is critical for virus entry and fusion.The herpes simplex virus JMP mutant enters receptor-negative J cells through a novel pathway independent of the known receptors nectin1, HveA, and nectin2.Hydrophobic alpha-helices 1 and 2 of herpes simplex virus gH interact with lipids, and their mimetic peptides enhance virus infection and fusion.Sustained FXN expression in dorsal root ganglia from a nonreplicative genomic HSV-1 vector.
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P2860
Substitution in the murine nectin1 receptor of a single conserved amino acid at a position distal from the herpes simplex virus gD binding site confers high-affinity binding to gD.
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2002 nî lūn-bûn
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2002年の論文
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2002年論文
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2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
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2002年论文
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2002年论文
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name
Substitution in the murine nec ...... s high-affinity binding to gD.
@en
Substitution in the murine nec ...... s high-affinity binding to gD.
@nl
type
label
Substitution in the murine nec ...... s high-affinity binding to gD.
@en
Substitution in the murine nec ...... s high-affinity binding to gD.
@nl
prefLabel
Substitution in the murine nec ...... s high-affinity binding to gD.
@en
Substitution in the murine nec ...... s high-affinity binding to gD.
@nl
P2093
P2860
P1433
P1476
Substitution in the murine nec ...... s high-affinity binding to gD.
@en
P2093
Carlo Bertucci
Laura Menotti
Marc Lopez
P2860
P304
P356
10.1128/JVI.76.11.5463-5471.2002
P407
P577
2002-06-01T00:00:00Z