The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation.
about
PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasisFbxw7 Tumor Suppressor: A Vital Regulator Contributes to Human TumorigenesisTargeting the ubiquitin pathway for cancer treatmentFBW7-mediated ubiquitination and degradation of KLF5The double life of KLF5: Opposing roles in regulation of gene-expression, cellular function, and transformationPrediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients.The role of aberrant proteolysis in lymphomagenesisDysregulation of ubiquitin ligases in cancerWogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradationDistinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas.Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation.miR-217 inhibits triple-negative breast cancer cell growth, migration, and invasion through targeting KLF5The induction of KLF5 transcription factor by progesterone contributes to progesterone-induced breast cancer cell proliferation and dedifferentiation.Aberrant regulation of FBW7 in cancer.Multilayer control of the EMT master regulators.Curcumin promotes KLF5 proteasome degradation through downregulating YAP/TAZ in bladder cancer cells.Multiple novel alternative splicing forms of FBXW7α have a translational modulatory function and show specific alteration in human cancer.Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.Ampelopsin induces apoptosis by regulating multiple c-Myc/S-phase kinase-associated protein 2/F-box and WD repeat-containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma cellsF-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous mannerIdentification of poly (ADP-ribose) polymerase-1 (PARP-1) as a novel Kruppel-like factor 8-interacting and -regulating proteinInhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice.The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein.Emerging roles of the FBW7 tumour suppressor in stem cell differentiation.Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5).BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5.The two faces of FBW7 in cancer drug resistance.Tumor suppressor functions of FBW7 in cancer development and progression.The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis.Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.Comprehensive Dissection of Transcriptome Data and Regulatory Factors in Pancreatic Cancer Cells.Evaluating the prognostic significance of FBXW7 expression level in human breast cancer by a meta-analysis of transcriptional profiles.ML264, A Novel Small-Molecule Compound That Potently Inhibits Growth of Colorectal Cancer.Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development.Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells.RNF115/BCA2 E3 ubiquitin ligase promotes breast cancer cell proliferation through targeting p21Waf1/Cip1 for ubiquitin-mediated degradation.Ubiquitin at the crossroad of cell death and survival.Tongxinluo inhibits neointimal formation by regulating the expression and post-translational modification of KLF5 in macrophages.Study of single nucleotide polymorphisms of FBW7 and its substrate genes revealed a predictive factor for paclitaxel plus cisplatin chemotherapy in Chinese patients with advanced esophageal squamous cell carcinoma.
P2860
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P2860
The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
The Fbw7 tumor suppressor targ ...... ses breast cell proliferation.
@en
The Fbw7 tumor suppressor targ ...... ses breast cell proliferation.
@nl
type
label
The Fbw7 tumor suppressor targ ...... ses breast cell proliferation.
@en
The Fbw7 tumor suppressor targ ...... ses breast cell proliferation.
@nl
prefLabel
The Fbw7 tumor suppressor targ ...... ses breast cell proliferation.
@en
The Fbw7 tumor suppressor targ ...... ses breast cell proliferation.
@nl
P2093
P1433
P1476
The Fbw7 tumor suppressor targ ...... ses breast cell proliferation.
@en
P2093
Ceshi Chen
Han-Qiu Zheng
Zhongmei Zhou
P304
P356
10.1158/0008-5472.CAN-10-0040
P407
P577
2010-05-18T00:00:00Z