Mechanism of DNA transesterification by vaccinia topoisomerase: catalytic contributions of essential residues Arg-130, Gly-132, Tyr-136 and Lys-167.
about
Structure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases.The integrase family of recombinase: organization and function of the active siteChemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry.New peptide inhibitors of type IB topoisomerases: similarities and differences vis-a-vis inhibitors of tyrosine recombinases.The role of histidine 632 in catalysis by human topoisomerase I.Reversible inhibitors of lambda integrase-mediated recombination efficiently trap Holliday junction intermediates and form the basis of a novel assay for junction resolution.A functional type I topoisomerase from Pseudomonas aeruginosa.Mechanism and specificity of DNA strand exchange catalyzed by vaccinia DNA topoisomerase type I.Vaccinia topoisomerase and Cre recombinase catalyze direct ligation of activated DNA substrates containing a 3'-para-nitrophenyl phosphate ester.A poxvirus-like type IB topoisomerase family in bacteria.Biochemical characterization of the topoisomerase domain of Methanopyrus kandleri topoisomerase V.Structural studies of type I topoisomerases.Nonpolar nucleobase analogs illuminate requirements for site-specific DNA cleavage by vaccinia topoisomerase.Identification of active site residues in Escherichia coli DNA topoisomerase I.Recombinogenic flap ligation pathway for intrinsic repair of topoisomerase IB-induced double-strand breaks.Chemical mutagenesis of vaccinia DNA topoisomerase lysine 167 provides insights to the catalysis of DNA transesterification.Mutational analysis of vaccinia virus topoisomerase identifies residues involved in DNA binding.Replacement of the active site tyrosine of vaccinia DNA topoisomerase by glutamate, cysteine or histidine converts the enzyme into a site-specific endonucleaseCharacterization of mimivirus DNA topoisomerase IB suggests horizontal gene transfer between eukaryal viruses and bacteria.Characterization of a mutation of bacteriophage lambda integrase. Putative role in core binding and strand exchange for a conserved residue.Intramolecular synapsis of duplex DNA by vaccinia topoisomerase.Mutational analysis of the archaeal tyrosine recombinase SSV1 integrase suggests a mechanism of DNA cleavage in trans.Crystal structure of a bacterial type IB DNA topoisomerase reveals a preassembled active site in the absence of DNA.Effect of 2'-5' phosphodiesters on DNA transesterification by vaccinia topoisomerase.Vaccinia topoisomerase mutants illuminate conformational changes during closure of the protein clamp and assembly of a functional active site.Fluorescence spectroscopy studies of vaccinia type IB DNA topoisomerase. Closing of the enzyme clamp is faster than DNA cleavage.Proton relay mechanism of general acid catalysis by DNA topoisomerase IB.Benzo[a]pyrene-dG adduct interference illuminates the interface of vaccinia topoisomerase with the DNA minor groove.Site-specific DNA transesterification by vaccinia topoisomerase: effects of benzo[alpha]pyrene-dA, 8-oxoguanine, 8-oxoadenine and 2-aminopurine modifications.Flexibility at Gly-194 is required for DNA cleavage and relaxation activity of Escherichia coli DNA topoisomerase I.Regulation of catalysis by the smallpox virus topoisomerase.Entirely enzymatic nanofabrication of DNA-protein conjugates.
P2860
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P2860
Mechanism of DNA transesterification by vaccinia topoisomerase: catalytic contributions of essential residues Arg-130, Gly-132, Tyr-136 and Lys-167.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Mechanism of DNA transesterifi ...... Gly-132, Tyr-136 and Lys-167.
@en
Mechanism of DNA transesterifi ...... Gly-132, Tyr-136 and Lys-167.
@nl
type
label
Mechanism of DNA transesterifi ...... Gly-132, Tyr-136 and Lys-167.
@en
Mechanism of DNA transesterifi ...... Gly-132, Tyr-136 and Lys-167.
@nl
prefLabel
Mechanism of DNA transesterifi ...... Gly-132, Tyr-136 and Lys-167.
@en
Mechanism of DNA transesterifi ...... Gly-132, Tyr-136 and Lys-167.
@nl
P2860
P356
P1476
Mechanism of DNA transesterifi ...... Gly-132, Tyr-136 and Lys-167.
@en
P2093
J Wittschieben
P2860
P304
P356
10.1093/NAR/25.15.3001
P407
P577
1997-08-01T00:00:00Z