about
A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivityHigh-throughput profiling of influenza A virus hemagglutinin gene at single-nucleotide resolutionA comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins.High-throughput profiling of point mutations across the HIV-1 genome.Systematic identification of H274Y compensatory mutations in influenza A virus neuraminidase by high-throughput screening.Modelling clinical data shows active tissue concentration of daclatasvir is 10-fold lower than its plasma concentration.A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure.Accurate viral population assembly from ultra-deep sequencing data.High-throughput identification of loss-of-function mutations for anti-interferon activity in the influenza A virus NS segment.Kaposi's sarcoma-associated herpesvirus ORF18 and ORF30 are essential for late gene expression during lytic replication.HIV-1 quasispecies delineation by tag linkage deep sequencingCoupling high-throughput genetics with phylogenetic information reveals an epistatic interaction on the influenza A virus M segment.A benchmark study on error-correction by read-pairing and tag-clustering in amplicon-based deep sequencingSystematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein.Adaptation in protein fitness landscapes is facilitated by indirect pathsChromosomal DNA deletion confers phage resistance to Pseudomonas aeruginosa.High-resolution genetic profile of viral genomes: why it matters.Quantifying perinatal transmission of Hepatitis B viral quasispecies by tag linkage deep sequencing.Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis.A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus.High-throughput identification of protein mutant stability computed from a double mutant fitness landscape.Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin.Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin.In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity.Immunochemical engineering of cell surfaces to generate virus resistance.Long Single-Molecule Reads Can Resolve the Complexity of the Influenza Virus Composed of Rare, Closely Related Mutant Variants.Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem.Short communication: HIV-1 gag genetic variation in a single acutely infected participant defined by high-resolution deep sequencingA comprehensive biophysical description of pairwise epistasis throughout an entire protein domain.Development of a versatile, target-oriented tiling microarray assay for measuring allele-specific gene expression.A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design.Structural insights into the design of novel anti-influenza therapies.A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site.Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variantsFully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody libraryBacterial Glycosyltransferase-mediated Cell-surface Chemoenzymatic Glycan Editing: Methods and ApplicationsClinical Correlations of Transcriptional Profile in Patients Infected With Avian Influenza H7N9 VirusAdaptive potential of a drug-targeted viral protein as a function of environmental stress
P50
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P50
description
hulumtues
@sq
researcher
@en
հետազոտող
@hy
name
Nicholas C Wu
@ast
Nicholas C Wu
@en
Nicholas C Wu
@es
Nicholas C Wu
@nl
Nicholas C Wu
@sl
type
label
Nicholas C Wu
@ast
Nicholas C Wu
@en
Nicholas C Wu
@es
Nicholas C Wu
@nl
Nicholas C Wu
@sl
prefLabel
Nicholas C Wu
@ast
Nicholas C Wu
@en
Nicholas C Wu
@es
Nicholas C Wu
@nl
Nicholas C Wu
@sl
P1053
H-3822-2015
P106
P108
P21
P31
P3829
P496
0000-0002-9078-6697