In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides. - Wikidata - awgldk - TriplyDB

In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides.

In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides.

http://www.wikidata.org/entity/Q39731474

about

Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver Antisense-mediated exon skipping: a versatile tool with therapeutic and research applications Intercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities.Preclinical and clinical development of siRNA-based therapeutics Exploring cellular activity of locked nucleic acid-modified triplex-forming oligonucleotides and defining its molecular basis.Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth.Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?Antineoplastic effect of decoy oligonucleotide derived from MGMT enhancer.Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy.Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo MicroRNAs in Liver Health and Disease Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies.The role of microRNAs in cancer.DNAzymes and cardiovascular disease.An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models.Anti-insulin-like growth factor-IIP3 DNAzymes inhibit cell proliferation and induce caspase-dependent apoptosis in human hepatocarcinoma cell lines MicroRNA-146b promotes adipogenesis by suppressing the SIRT1-FOXO1 cascade Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics.Antisense gapmers selectively suppress individual oncogenic p73 splice isoforms and inhibit tumor growth in vivo.Biological barriers to therapy with antisense and siRNA oligonucleotides.Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides.The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides.Antisense drug discovery and development.Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals.MicroRNAs in neurodegenerative diseases and their therapeutic potential.Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides.Canonical and non-canonical barriers facing antimiR cancer therapeutics Exon-skipping antisense oligonucleotides to correct missplicing in neurogenetic diseases.DNAzyme-based biosensors and nanodevices.Epigenetic targets for novel therapies of lung diseases.Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation.Nuclear expression of Y-box binding protein-1 is associated with poor prognosis in patients with pancreatic cancer and its knockdown inhibits tumor growth and metastasis in mice tumor models.EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells.Long and short noncoding RNAs in lung cancer precision medicine: Opportunities and challenges.Therapeutic Potentials of Noncoding RNAs: Targeted Delivery of ncRNAs in Cancer Cells.Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA.Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes NMR solution structure of a parallel LNA quadruplex.

P2860

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P2860

In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides.

http://www.wikidata.org/entity/Q39731474

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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name

In vivo tumor growth inhibitio ...... A) antisense oligonucleotides.

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In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid

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type

label

In vivo tumor growth inhibitio ...... A) antisense oligonucleotides.

@en

In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid

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In vivo tumor growth inhibitio ...... A) antisense oligonucleotides.

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In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid

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In vivo tumor growth inhibitio ...... A) antisense oligonucleotides.

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Anneloor L M A ten Asbroek

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Henrik Oerum

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Håkan Olsson

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Margit Wissenbach

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Marit B de Wissel

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Marja E Jakobs

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Otto Olsen

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P2860

Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

RNA polymerase II and the integration of nuclear events

Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides.

Antisense PNA tridecamers targeted to the coding region of Ha-ras mRNA arrest polypeptide chain elongation.

Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA.

UV light-induced degradation of RNA polymerase II is dependent on the Cockayne's syndrome A and B proteins but not p53 or MLH1.

Phase I study of an antisense oligonucleotide to protein kinase C-alpha (ISIS 3521/CGP 64128A) in patients with cancer.

Two problems in antisense biotechnology: in vitro delivery and the design of antisense experiments.

Importance of nucleotide sequence and chemical modifications of antisense oligonucleotides.

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10.1093/NAR/GKG185

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