Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK. - Wikidata - awgldk - TriplyDB

Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.

Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.

http://www.wikidata.org/entity/Q39757718

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Atg7 in development and disease: panacea or Pandora's Box?Caloric restriction: is mammalian life extension linked to p53?Mitochondria and the autophagy-inflammation-cell death axis in organismal aging The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells Hormesis, cell death and aging.Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer.Cell death in disease: from 2010 onwards Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling.Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process BCL-2 Antagonism to Target the Intrinsic Mitochondrial Pathway of Apoptosis.Delving deeper: MCL-1's contributions to normal and cancer biology.Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC-DLBCL cells in vitro and in vivo GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells.BAG3-dependent noncanonical autophagy induced by proteasome inhibition in HepG2 cells Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker.Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer Role of the promyelocytic leukaemia protein in cell death regulation.Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy.Targeting intrinsic apoptosis and other forms of cell death by BH3-mimetics in glioblastoma.Combating autophagy is a strategy to increase cytotoxic effects of novel ALK inhibitor entrectinib in neuroblastoma cells.Beclin-1 Deficiency Alters Autophagosome Formation, Lysosome Biogenesis and Enhances Neuronal Vulnerability of HT22 Hippocampal Cells.Cell death induction by the BH3 mimetic GX15-070 in thyroid carcinoma cells Survival control of malignant lymphocytes by anti-apoptotic MCL-1.Obatoclax induces Beclin 1- and ATG5-dependent apoptosis and autophagy in adenoid cystic carcinoma cells.Obatoclax induces G1/G0-phase arrest via p38/p21(waf1/Cip1) signaling pathway in human esophageal cancer cells.miR-106a suppresses tumor cells death in colorectal cancer through targeting ATG7.Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes.Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer.The BH3 mimetic HA14-1 enhances 5-fluorouracil-induced autophagy and type II cell death in oesophageal cancer cells.A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers.The BH3 mimetic drug ABT-737 induces apoptosis and acts synergistically with chemotherapeutic drugs in thyroid carcinoma cells.BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells.Anti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors.5-Aminoimidazole-4-carboxamide ribonucleoside-induced autophagy flux during differentiation of monocytic leukemia cells.Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications.

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Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.

http://www.wikidata.org/entity/Q39757718

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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2010年學術文章

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name

Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.

@en

Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.

@nl

type

label

Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.

@en

Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.

@nl

prefLabel

Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.

@en

Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.

@nl

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Cell Death and Disease

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Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK

@en

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B O'Hagan

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C Barnes

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D A Fennell

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D Longley

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F McCoy

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G McKerr

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J Hurwitz

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P2860

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

The Hallmarks of Cancer

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

BH3 mimetics to improve cancer therapy; mechanisms and examples

Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

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e108

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10.1038/CDDIS.2010.86

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1

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James T. Murray

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2010-12-16T00:00:00Z

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