Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements.
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Alternative end-joining mechanisms: a historical perspectiveTelomere dysfunction and chromosome instabilityMicrohomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?Variation at the TERT locus and predisposition for cancerTelomere fusions in early human breast carcinoma.The presence of telomere fusion in sporadic colon cancer independently of disease stage, TP53/KRAS mutation status, mean telomere length, and telomerase activityBone marrow failure and the telomeropathies.Diet-related telomere shortening and chromosome stabilityTelomere fusion threshold identifies a poor prognostic subset of breast cancer patients.Knock-Down of the 37kDa/67kDa Laminin Receptor LRP/LR Impedes Telomerase ActivityChromothripsis and Kataegis Induced by Telomere CrisisTelomere length measurement-caveats and a critical assessment of the available technologies and toolsMechanisms of telomere loss and their consequences for chromosome instability.Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks.Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasiaComplex interactions between the DNA-damage response and mammalian telomeres.Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4.Risky business: Microhomology-mediated end joining.Alternative end joining, clonal evolution, and escape from a telomere-driven crisis.Stop pulling my strings - what telomeres taught us about the DNA damage response.Telomere dysfunction and its role in haematological cancer.The role of dicentric chromosome formation and secondary centromere deletion in the evolution of myeloid malignancy.Novel patented therapeutic approaches targeting the 37/67 kDa laminin receptor for treatment of cancer and Alzheimer's disease.Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions.Mre11 modulates the fidelity of fusion between short telomeres in human cells.The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion.Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells.Acentric chromosome ends are prone to fusion with functional chromosome ends through a homology-directed rearrangement.DNA synthesis generates terminal duplications that seal end-to-end chromosome fusions.Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability.37 kDa LRP::FLAG enhances telomerase activity and reduces senescent markers in vitro.Differences in the recruitment of DNA repair proteins at subtelomeric and interstitial I-SceI endonuclease-induced DNA double-strand breaks.Telomere length is a critical determinant for survival in multiple myeloma.Simple Detection of Telomere Fusions in Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm, and Pancreatic Cyst Fluid.Telomere Length Dynamics and the Evolution of Cancer Genome Architecture.Shortened telomeres: a driving force behind leukemia?Telomeres and genomic evolution.PARP1 is required for preserving telomeric integrity but is dispensable for A-NHEJThe Breakage-Fusion-Bridge Cycle ProducingMLLAmplification in a Case of Myelodysplastic Syndrome
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P2860
Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Fusion of short telomeres in h ...... ult in complex rearrangements.
@en
Fusion of short telomeres in h ...... ult in complex rearrangements.
@nl
type
label
Fusion of short telomeres in h ...... ult in complex rearrangements.
@en
Fusion of short telomeres in h ...... ult in complex rearrangements.
@nl
prefLabel
Fusion of short telomeres in h ...... ult in complex rearrangements.
@en
Fusion of short telomeres in h ...... ult in complex rearrangements.
@nl
P2860
P356
P1476
Fusion of short telomeres in h ...... sult in complex rearrangements
@en
P2093
Boitelo T Letsolo
Jan Rowson
P2860
P304
P356
10.1093/NAR/GKP1183
P407
P50
P577
2009-12-21T00:00:00Z