High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors. - Wikidata - awgldk - TriplyDB

High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors.

High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors.

http://www.wikidata.org/entity/Q39768618

about

Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells MinION: A Novel Tool for Predicting Drug Hypersensitivity?Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology.Demethylating Agents in the Treatment of Cancer A DNMT3B alternatively spliced exon and encoded peptide are novel biomarkers of human pluripotent stem cells Germ cell cancer presenting as gastrointestinal bleeding and developing brain metastases: case report and review of the literature.Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation.An alkylphenol mix promotes seminoma derived cell proliferation through an ERalpha36-mediated mechanism.Serine/threonine kinase 17A is a novel candidate for therapeutic targeting in glioblastoma Generation of tumor-initiating cells by exogenous delivery of OCT4 transcription factor.Inhibition of DNA methyltransferase as a novel therapeutic strategy to overcome acquired resistance to dual PI3K/mTOR inhibitors.DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors.Manipulating the epigenome for the treatment of urological malignancies.Testicular germ cell tumours: predisposition genes and the male germ cell niche.Hypomethylating agents for urologic cancers.The role of BLIMP1 and its putative downstream target TFAP2C in germ cell development and germ cell tumours.Treatment of patients with relapsed and/or cisplatin-refractory metastatic germ cell tumours: an update.RASSF Signalling and DNA Damage: Monitoring the Integrity of the Genome?Unravelling mechanisms of cisplatin sensitivity and resistance in testicular cancer.Cisplatin resistance in germ cell tumours: models and mechanisms.Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries.Epigenetic drugs for cancer treatment and prevention: mechanisms of action.Emerging Therapeutic Targets for Male Germ Cell Tumors.Postchemotherapy changes in testicular germ cell tumours: biology and morphology.Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives.Investigational targeted therapies for the treatment of testicular germ cell tumors.Platinum-refractory germ cell tumors: an update on current treatment options and developments.Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine.Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy.MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review.Targeting DNA Methyltranferases in Urological Tumors.

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P2860

High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors.

http://www.wikidata.org/entity/Q39768618

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh

2009年學術文章

@zh-hant

name

High DNA methyltransferase 3B ...... n testicular germ cell tumors.

@en

High DNA methyltransferase 3B ...... n testicular germ cell tumors.

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type

label

High DNA methyltransferase 3B ...... n testicular germ cell tumors.

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High DNA methyltransferase 3B ...... n testicular germ cell tumors.

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prefLabel

High DNA methyltransferase 3B ...... n testicular germ cell tumors.

@en

High DNA methyltransferase 3B ...... n testicular germ cell tumors.

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0008-5472.CAN-09-1490

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Cancer Research

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High DNA methyltransferase 3B ...... n testicular germ cell tumors.

@en

P2093

Alan Eastman

http://www.w3.org/2001/XMLSchema#string

Ethan Dmitrovsky

http://www.w3.org/2001/XMLSchema#string

Kristen M Garner

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Maroun J Beyrouthy

http://www.w3.org/2001/XMLSchema#string

Mary P Hever

http://www.w3.org/2001/XMLSchema#string

Michael J Spinella

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Sarah J Freemantle

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P2860

Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine

Curing metastatic testicular cancer

Characteristic promoter hypermethylation signatures in male germ cell tumors

The epigenomics of cancer

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1).

Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors.

Regulatory networks define phenotypic classes of human stem cell lines.

Long-term complications of chemotherapy for germ cell tumours.

The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins.

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9360-9366

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19951990

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