Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions.
about
Molecular and functional properties of P2X receptors--recent progress and persisting challengesInsights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide PolymorphismsUse of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes.The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice.Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain.Mutation of putative N-linked glycosylation sites on the human nucleotide receptor P2X7 reveals a key residue important for receptor function.Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkersLack of association of P2RX7 gene rs2230912 polymorphism with mood disorders: a meta-analysis.Activation and regulation of purinergic P2X receptor channelsGenetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome.Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions.Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor FunctionSingle-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fracturesStructure-based identification and characterisation of structurally novel human P2X7 receptor antagonistsMultiplicative interaction of functional inflammasome genetic variants in determining the risk of gout.P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients.Role of inflammatory cytokines in depression: Focus on interleukin-1β.Structural and molecular modeling features of P2X receptors.Functional variant of the P2X7 receptor gene is associated with human papillomavirus-16 positive cervical squamous cell carcinoma.Heteromeric assembly of P2X subunits.Correlation between P2X7 receptor gene polymorphisms and gout.Pharmacological properties of the rhesus macaque monkey P2X7 receptor.Investigation into the association between P2RX7 gene polymorphisms and susceptibility to primary gout and hyperuricemia in a Chinese Han male population.P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells.C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation.Single nucleotide polymorphisms associated with P2X7R function regulate the onset of gouty arthritis.ATP-induced P2X Receptor-Dependent Large Pore Formation: How Much Do We Know?Structural insights into the competitive inhibition of the ATP-gated P2X receptor channelRegulation of activity of P2X7 receptor by its splice variants in cultured mouse astrocytes.A phase I clinical trial demonstrates that nfP2X7 -targeted antibodies provide a novel, safe and tolerable topical therapy for basal cell carcinoma.Residues 155 and 348 contribute to the determination of P2X7 receptor function via distinct mechanisms revealed by single-nucleotide polymorphisms.Purinergic P2X7 receptor functional genetic polymorphisms are associated with the susceptibility to osteoporosis in Chinese postmenopausal women.Purinergic system in psychiatric diseases.Genetic interaction of purinergic P2X7 receptor and ER-α polymorphisms in susceptibility to osteoporosis in Chinese postmenopausal women.The P2X7 Receptor.The P2X7 receptor and pannexin-1 are involved in glucose-induced autocrine regulation in β-cells.
P2860
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P2860
Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Single nucleotide polymorphism ...... vated P2X7 receptor functions.
@en
Single nucleotide polymorphism ...... vated P2X7 receptor functions.
@en-gb
Single nucleotide polymorphism ...... vated P2X7 receptor functions.
@nl
type
label
Single nucleotide polymorphism ...... vated P2X7 receptor functions.
@en
Single nucleotide polymorphism ...... vated P2X7 receptor functions.
@en-gb
Single nucleotide polymorphism ...... vated P2X7 receptor functions.
@nl
prefLabel
Single nucleotide polymorphism ...... vated P2X7 receptor functions.
@en
Single nucleotide polymorphism ...... vated P2X7 receptor functions.
@en-gb
Single nucleotide polymorphism ...... vated P2X7 receptor functions.
@nl
P2093
P50
P1476
Single nucleotide polymorphism ...... vated P2X7 receptor functions.
@en
P2093
Annmarie Surprenant
Helen Bradley
Jocelyn M Baldwin
Zhu-Zhong Mei
P304
P356
10.1016/J.JPSYCHIRES.2009.10.005
P577
2009-11-20T00:00:00Z