Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss - Wikidata - awgldk - TriplyDB

Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss

Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss

http://www.wikidata.org/entity/Q39782322

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ACAT2 and human hepatic cholesterol metabolism: identification of important gender-related differences in normolipidemic, non-obese Chinese patients A new model of reverse cholesterol transport: enTICEing strategies to stimulate intestinal cholesterol excretion The thyroid receptor modulator KB3495 reduces atherosclerosis independently of total cholesterol in the circulation in ApoE deficient mice Modulating the Gut Microbiota Improves Glucose Tolerance, Lipoprotein Profile and Atherosclerotic Plaque Development in ApoE-Deficient Mice A new framework for reverse cholesterol transport: non-biliary contributions to reverse cholesterol transport.Dynamics of hepatic and intestinal cholesterol and bile acid pathways: The impact of the animal model of estrogen deficiency and exercise training Role of the intestinal bile acid transporters in bile acid and drug disposition The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome A reappraisal of the mechanism by which plant sterols promote neutral sterol loss in mice TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2.Both the peroxisome proliferator-activated receptor delta agonist, GW0742, and ezetimibe promote reverse cholesterol transport in mice by reducing intestinal reabsorption of HDL-derived cholesterol Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion.Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization Biliary sterol secretion is not required for macrophage reverse cholesterol transport Cholesterol esters (CE) derived from hepatic sterol O-acyltransferase 2 (SOAT2) are associated with more atherosclerosis than CE from intestinal SOAT2 Reverse cholesterol transport is elevated in carboxyl ester lipase-knockout mice Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles.Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis.Adipose-selective overexpression of ABHD5/CGI-58 does not increase lipolysis or protect against diet-induced obesity.CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action.Protein mediators of sterol transport across intestinal brush border membrane.Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood.Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies.Trust your gut: galvanizing nutritional interest in intestinal cholesterol metabolism for protection against cardiovascular diseases The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A.Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice.Biliary and nonbiliary contributions to reverse cholesterol transport.Acyl-coenzyme A:cholesterol acyltransferases.Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol.Influence of class B scavenger receptors on cholesterol flux across the brush border membrane and intestinal absorption.Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in monkeys.Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein.Sterol O-Acyltransferase 2-Driven Cholesterol Esterification Opposes Liver X Receptor-Stimulated Fecal Neutral Sterol Loss.Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse.Reverse cholesterol transport: from classical view to new insights.Biliary cholesterol secretion: more than a simple ABC.From blood to gut: direct secretion of cholesterol via transintestinal cholesterol efflux.Intestinal nuclear receptors in HDL cholesterol metabolism.An integrated approach for the mechanisms responsible for atherosclerotic plaque regression

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P2860

Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss

http://www.wikidata.org/entity/Q39782322

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2008 nî lūn-bûn

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Targeted depletion of hepatic ...... for fecal neutral sterol loss

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Targeted depletion of hepatic ...... for fecal neutral sterol loss

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Targeted depletion of hepatic ...... for fecal neutral sterol loss

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Journal of Biological Chemistry

P1476

Targeted depletion of hepatic ...... for fecal neutral sterol loss

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P2093

Heather M Alger

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J Mark Brown

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Janet K Sawyer

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Kathryn Kelley

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Lawrence L Rudel

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Mark J Graham

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Martha D Wilson

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Matthew A Davis

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Ramesh Shah

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Richard G Lee

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P2860

ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Studies on the production of low density lipoproteins by perfused livers from nonhuman primates. Effect of dietary cholesterol.

Regulation of plasma cholesterol by lipoprotein receptors.

Absorption of cholesterol from a micellar solution: intestinal perfusion studies in man

Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice.

Control of cholesterol turnover in the mouse.

Sterol absorption by the small intestine.

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10522-10534

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10.1074/JBC.M707659200

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16

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283

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