The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicans.
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Genomic Plasticity of the Human Fungal Pathogen Candida albicansGenetic and phenotypic intra-species variation in Candida albicansMechanisms of Candida biofilm drug resistanceUpregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitorsThe transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicansPKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?Evolution of microbial pathogens.Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target siteThe parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the formation of recombinant strains.Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing.Genetic analysis of azole resistance in the Darlington strain of Candida albicans.Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents.Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrataIdentification and expression of multidrug transporters responsible for fluconazole resistance in Candida dubliniensisRapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR.Mechanism of fluconazole resistance in Candida krusei.Distinct patterns of gene expression associated with development of fluconazole resistance in serial candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis.Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance.Rapid acquisition of stable azole resistance by Candida glabrata isolates obtained before the clinical introduction of fluconazole.Efg1 involved in drug resistance by regulating the expression of ERG3 in Candida albicans.Amino acid substitutions at the major insertion loop of Candida albicans sterol 14alpha-demethylase are involved in fluconazole resistance.Functional characterization of Candida albicans Hos2 histone deacetylase.Quantitation of ergosterol content: novel method for determination of fluconazole susceptibility of Candida albicansFormation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450Effects of azole antifungal drugs on the transition from yeast cells to hyphae in susceptible and resistant isolates of the pathogenic yeast Candida albicans.Multiple resistant phenotypes of Candida albicans coexist during episodes of oropharyngeal candidiasis in human immunodeficiency virus-infected patientsAccumulation of 3-ketosteroids induced by itraconazole in azole-resistant clinical Candida albicans isolates.Proton-pumping-ATPase-targeted antifungal activity of a novel conjugated styryl ketone.Enhanced extracellular production of aspartyl proteinase, a virulence factor, by Candida albicans isolates following growth in subinhibitory concentrations of fluconazole.Experimental induction of fluconazole resistance in Candida tropicalis ATCC 750Quantitation of Candida albicans ergosterol content improves the correlation between in vitro antifungal susceptibility test results and in vivo outcome after fluconazole treatment in a murine model of invasive candidiasis.Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patientsTandem repeat of a transcriptional enhancer upstream of the sterol 14alpha-demethylase gene (CYP51) in Penicillium digitatum.Specific chromosome alterations in fluconazole-resistant mutants of Candida albicans.The role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity.Correlation between azole susceptibilities, genotypes, and ERG11 mutations in Candida albicans isolates associated with vulvovaginal candidiasis in China.Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeableA clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.
P2860
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P2860
The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicans.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
The presence of an R467K amino ...... methylase in Candida albicans.
@en
The presence of an R467K amino ...... methylase in Candida albicans.
@nl
type
label
The presence of an R467K amino ...... methylase in Candida albicans.
@en
The presence of an R467K amino ...... methylase in Candida albicans.
@nl
prefLabel
The presence of an R467K amino ...... methylase in Candida albicans.
@en
The presence of an R467K amino ...... methylase in Candida albicans.
@nl
P2860
P1476
The presence of an R467K amino ...... methylase in Candida albicans.
@en
P2093
P2860
P304
P407
P577
1997-07-01T00:00:00Z