The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis.
about
Eph/ephrin molecules--a hub for signaling and endocytosisGene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab.PEGylation potentiates the effectiveness of an antagonistic peptide that targets the EphB4 receptor with nanomolar affinityThe small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesisEph receptors and ephrins in cancer: bidirectional signalling and beyond.Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis.RHOA inactivation enhances Wnt signalling and promotes colorectal cancer.The tumour-promoting receptor tyrosine kinase, EphB4, regulates expression of integrin-β8 in prostate cancer cells.The role of EphB4 and IGF-IR expression in breast cancer cellsEphA2 silencing promotes growth, migration, and metastasis in salivary adenoid cystic carcinoma: in vitro and in vivo studyEphB4/ephrinB2 Contributes to Imatinib Resistance in Chronic Myeloid Leukemia Involved in Cytoskeletal Proteins.Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer.Loss of the EPH receptor B6 contributes to colorectal cancer metastasisEph-dependent cell-cell adhesion and segregation in development and cancer.Novel targets for VEGF-independent anti-angiogenic drugs.What are the best routes to effectively model human colorectal cancer?The dynamics of developmental and tumor angiogenesis-a comparison.Therapeutic targeting of EPH receptors and their ligands.Eph family co-expression patterns define unique clusters predictive of cancer phenotype.The Effect of Analogues of 1α,25-Dihydroxyvitamin D₂ on the Regrowth and Gene Expression of Human Colon Cancer Cells Refractory to 5-Fluorouracil.EphB4 regulates the growth and migration of pancreatic cancer cells.Suppression of EphB4 improves the inhibitory effect of mTOR shRNA on the biological behaviors of ovarian cancer cells by down-regulating Akt phosphorylation.Evidence for a dual function of EphB4 as tumor promoter and suppressor regulated by the absence or presence of the ephrin-B2 ligand.Cancer cells exploit the Eph-ephrin system to promote invasion and metastasis: tales of unwitting partners.Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis.Biochemical and biophysical characterization of four EphB kinase domains reveals contrasting thermodynamic, kinetic and inhibition profiles.Aberrant EPHB4 gene methylation and childhood acute lymphoblastic leukemia.The antitumor effect of arsenic trioxide on hepatocellular carcinoma is enhanced by andrographolide.Incidence of second primary malignancies and related mortality in patients with imatinib-treated chronic myeloid leukemia.Activation of multiple angiogenic signaling pathways in hemangiopericytoma.lncRNA BC005927 upregulates EPHB4 and promotes gastric cancer metastasis under hypoxia.Prognostic Value of ACVRL1 Expression in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy With Bevacizumab: Results From the Triplet Plus Bevacizumab (TRIBE) Study.Brush border myosin Ia inactivation in gastric but not endometrial tumors.N-(2,4)-dinitrophenyl-L-arginine Interacts with EphB4 and Functions as an EphB4 Kinase Modulator.
P2860
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P2860
The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
The receptor tyrosine kinase E ...... s in intestinal tumorigenesis.
@en
The receptor tyrosine kinase E ...... s in intestinal tumorigenesis.
@nl
type
label
The receptor tyrosine kinase E ...... s in intestinal tumorigenesis.
@en
The receptor tyrosine kinase E ...... s in intestinal tumorigenesis.
@nl
prefLabel
The receptor tyrosine kinase E ...... s in intestinal tumorigenesis.
@en
The receptor tyrosine kinase E ...... s in intestinal tumorigenesis.
@nl
P2093
P50
P1433
P1476
The receptor tyrosine kinase E ...... es in intestinal tumorigenesis
@en
P2093
Andrew J Wilson
Jordi Romero
Julio Castaño
Marielle Esteves
Rocco Mazzolini
Silvia Mateo-Lozano
P304
P356
10.1158/0008-5472.CAN-09-0706
P407
P50
P577
2009-09-08T00:00:00Z