Targeting glucosylceramide synthase downregulates expression of the multidrug resistance gene MDR1 and sensitizes breast carcinoma cells to anticancer drugs.
about
Development, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance.Doxorubicin influences the expression of glucosylceramide synthase in invasive ductal breast cancerAltered methylation of glucosylceramide synthase promoter regulates its expression and associates with acquired multidrug resistance in invasive ductal breast cancer.Expression of glucosylceramide synthase in invasive ductal breast cancer may be correlated with high estrogen receptor status and low HER-2 statusTherapeutic potential of targeting ceramide/glucosylceramide pathway in cancer.Trametenolic acid B reverses multidrug resistance in breast cancer cells through regulating the expression level of P-glycoprotein.MDR1 (multidrug resistence 1) can regulate GCS (glucosylceramide synthase) in breast cancer cells.C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth.Inhibition of hepatocellular carcinoma growth by blockade of glycosphingolipid synthesis.The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1).
P2860
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P2860
Targeting glucosylceramide synthase downregulates expression of the multidrug resistance gene MDR1 and sensitizes breast carcinoma cells to anticancer drugs.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
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2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
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2009年學術文章
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name
Targeting glucosylceramide syn ...... oma cells to anticancer drugs.
@en
Targeting glucosylceramide syn ...... oma cells to anticancer drugs.
@nl
type
label
Targeting glucosylceramide syn ...... oma cells to anticancer drugs.
@en
Targeting glucosylceramide syn ...... oma cells to anticancer drugs.
@nl
prefLabel
Targeting glucosylceramide syn ...... oma cells to anticancer drugs.
@en
Targeting glucosylceramide syn ...... oma cells to anticancer drugs.
@nl
P2093
P2860
P1476
Targeting glucosylceramide syn ...... oma cells to anticancer drugs.
@en
P2093
Gengyin Zhou
Jianping Zhang
Tingguo Zhang
Wenxin Zheng
Xiaojuan Wu
Yanlin Sun
P2860
P2888
P304
P356
10.1007/S10549-009-0513-Z
P407
P577
2009-08-20T00:00:00Z