about
Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptorBiosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathwaySalvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerationsThe G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivoAplysinopsins--marine indole alkaloids: chemistry, bioactivity and ecological significance.Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skinUnusual hemiacetal structure derived from Salvinorin A.Identification of novel functionally selective κ-opioid receptor scaffolds.Pathways and products for the metabolism of vitamin D3 by cytochrome P450sccThe hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation-induced hypermotility in mice.Labdane diterpenoids from Leonurus sibiricus.Salvinorins J from Salvia divinorum: mutarotation in the neoclerodane system.Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol.Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in miceLabdane diterpenoids from Leonotis leonurus.Novel activities of CYP11A1 and their potential physiological significance.Short synthesis of a novel class of salvinorin A analogs with hemiacetalic structure.Triterpenoids and flavonoids from Cecropia schreberiana Miq. (Urticaceae)Oleanolic acid acrylate elicits antidepressant-like effect mediated by 5-HT1A receptorInhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between kappa-opioid and cannabinoid CB(1) receptors.Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives.Phytochemical investigation of Cycas circinalis and Cycas revoluta leaflets: moderately active antibacterial biflavonoidsNovel vitamin D photoproducts and their precursors in the skin.Salvinorin A Inhibits Airway Hyperreactivity Induced by Ovalbumin Sensitization.Selective natural kappa opioid and cannabinoid receptor agonists with a potential role in the treatment of gastrointestinal dysfunction.Preclinical Assessment of Cardiovascular Alterations Induced by Birch Polypore Mushroom, Piptoporus betulinus (Agaricomycetes).Semisynthesis of new sarcophine derivatives with chemopreventive activity.Novel orally available salvinorin A analog PR-38 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome.Synthesis and photochemical transformation of 3β,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity.Chemical synthesis of 20S-hydroxyvitamin D3, which shows antiproliferative activity.A new steroidal 5,7-diene derivative, 3beta-hydroxyandrosta-5,7-diene-17beta-carboxylic acid, shows potent anti-proliferative activity.Nitric Oxide Inhibitory Meroterpenoids from the Fungus Penicillium purpurogenum MHZ 111.Nitric Oxide Inhibitory Dimeric Sesquiterpenoids from Artemisia rupestris.Anti-inflammatory Labdane Diterpenoids from Leonurus macranthus.Anti-inflammatory coumarin and benzocoumarin derivatives from Murraya alata.An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2.The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism.Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor.Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection.
P50
Q24646341-EEAB138A-B944-4C52-B8D8-E72D7E51B0E5Q24682033-5884245C-E7EA-4728-B00F-4F8768DA17DAQ28238385-4612C1D3-CAB6-4140-9275-CA188A385176Q28249800-7CCAA4C6-2A74-4F77-93D9-8992BCB87B07Q33481650-D571750F-F7B5-49FE-9B9C-4E64256BC73BQ33548669-6E37C49C-BD4D-4186-A238-A790203784E0Q33947573-49FAE10F-2D0A-463E-AB37-38BE4C4E9DCAQ34229894-4A5B8AEF-1734-40D7-9AC3-F14C271BE9F9Q34376764-7558672F-5852-4A21-AC13-B895D6FB6E92Q34656104-BB5FDFE1-8393-47FE-ABEB-E3FE5D9B5585Q34700338-A4AFBB74-C689-4241-B056-A3FD19D0B3B7Q34851052-34B61062-7680-4458-BFD0-2F3353B4273EQ34983288-15AC3341-ED0A-4B37-A688-09700B76ED7CQ35776648-932F01A8-A438-4253-B2FC-0B68870AAE0EQ36016427-DB047F76-C640-4E67-AB25-797AA91D0A84Q36078329-2CFF88EA-7890-4C1E-8B18-50EB03636DBCQ36591625-6B351D89-E8E4-4221-84E5-5FB31ECD8650Q36591849-7769DB49-D9DD-469E-BBEB-4F333835D055Q36634378-E9CB6BFA-47A6-4ACE-8423-D89306B9D14CQ36972557-30BB9491-F7F4-46C7-962D-85B7FB3936EBQ36977483-3AF994C9-1FC1-40D2-B8DD-14A67E9B2849Q37003659-DD1D3AE3-EEAF-4913-A080-2FB10057E8B4Q37011731-0E621B65-C320-49CE-AE07-DD382DD4E401Q37499996-DC703C38-1094-4F59-B36D-617C065EF4B1Q37583981-13CDB6A1-4613-4AD4-BE34-5004E2A6DE96Q37627586-B9B34661-7A98-45F3-A156-997321D01877Q38729960-ECA9C4FF-091E-44A7-9BC6-0098EEA178BBQ39123795-EC7508CC-8EF5-427D-AD4F-FC61A224C30AQ39181583-C3BFD2B1-138F-414D-91C0-1D00880CFCCDQ39633004-FDD56DCB-9CC3-4B68-BB0D-44E7ED71253EQ39694085-77FED5D0-0025-4A24-8461-CFD1814187CBQ39814167-BBBAF8FC-8497-40F2-8D0C-69D461C08B03Q39817125-ED895AE2-C37C-4785-A8B1-762EBF268FBEQ40179220-E0DB220E-EB43-4172-8E6C-1508D77D6874Q40563486-ACC9D1D4-9974-43A7-B841-FCE61A3CC354Q41525536-642C20F1-AE35-4B90-BC75-2882241AFFDAQ41951711-8E5DB780-C459-4700-92BD-6D533DF75925Q41954026-59AF2DFF-86DE-4EA9-98C5-FD6A6C442702Q42141072-2205A289-1511-483D-B243-A5B478D29092Q42411070-D8BF40BF-AEE8-490E-8D77-79A4DC73E128
P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Jordan Zjawiony
@ast
Jordan Zjawiony
@en
Jordan Zjawiony
@es
Jordan Zjawiony
@nl
Jordan Zjawiony
@sl
type
label
Jordan Zjawiony
@ast
Jordan Zjawiony
@en
Jordan Zjawiony
@es
Jordan Zjawiony
@nl
Jordan Zjawiony
@sl
prefLabel
Jordan Zjawiony
@ast
Jordan Zjawiony
@en
Jordan Zjawiony
@es
Jordan Zjawiony
@nl
Jordan Zjawiony
@sl
P106
P1153
6603822246
P21
P31
P496
0000-0001-5242-2799