TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A. - Wikidata - awgldk - TriplyDB

TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A.

TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A.

http://www.wikidata.org/entity/Q39816829

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Anoctamin 6 is an essential component of the outwardly rectifying chloride channel CFTR and TMEM16A are separate but functionally related Cl- channels The Ca(2+) -activated Cl(-) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation Hypotonic shock modulates Na(+) current via a Cl(-) and Ca(2+)/calmodulin dependent mechanism in alveolar epithelial cells Acidic amino acids in the first intracellular loop contribute to voltage- and calcium- dependent gating of anoctamin1/TMEM16A.Recessive mutations in the putative calcium-activated chloride channel Anoctamin 5 cause proximal LGMD2L and distal MMD3 muscular dystrophies.A founder mutation in Anoctamin 5 is a major cause of limb-girdle muscular dystrophy.Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells Escherichia coli alpha-hemolysin triggers shrinkage of erythrocytes via K(Ca)3.1 and TMEM16A channels with subsequent phosphatidylserine exposure.ANO1 as a marker of oral squamous cell carcinoma and silencing ANO1 suppresses migration of human SCC-25 cells.Control of volume-sensitive chloride channel inactivation by the coupled action of intracellular chloride and extracellular protons Evolution and functional divergence of the anoctamin family of membrane proteins Role of the Ca2+ -activated Cl- channels bestrophin and anoctamin in epithelial cells.Anoctamin 6 differs from VRAC and VSOAC but is involved in apoptosis and supports volume regulation in the presence of Ca2+.Anoctamins.Differential contribution of SLC26A9 to Cl(-) conductance in polarized and non-polarized epithelial cells.Expression profile and protein translation of TMEM16A in murine smooth muscle.Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen.Modulating Ca²⁺ signals: a common theme for TMEM16, Ist2, and TMC.Activation of the basolateral membrane Cl- conductance essential for electrogenic K+ secretion suppresses electrogenic Cl- secretion.Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion.Anoctamin 6 regulates C2C12 myoblast proliferation Molecular and functional significance of Ca(2+)-activated Cl(-) channels in pulmonary arterial smooth muscle.A Coding Variant of ANO10, Affecting Volume Regulation of Macrophages, Is Associated with Borrelia Seropositivity.Identification of a lipid scrambling domain in ANO6/TMEM16F.Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex.Gingival tissue transcriptomes in experimental gingivitis Regional differences in rat conjunctival ion transport activities Knockdown of TMEM16A suppressed MAPK and inhibited cell proliferation and migration in hepatocellular carcinoma.Mechanosensitive Cl- secretion in biliary epithelium mediated through TMEM16A.Control of TMEM16A by INO-4995 and other inositolphosphates.Novel Use for DOG1 in Discriminating Breast Invasive Carcinoma from Noninvasive Breast Lesions Characterization of Rat Meibomian Gland Ion and Fluid Transport.TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels Developmental Role of Anoctamin-1/TMEM16A in Ca(2+)-Dependent Volume Change in Supporting Cells of the Mouse Cochlea.Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells

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TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A.

http://www.wikidata.org/entity/Q39816829

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

@zh-sg

2009年學術文章

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2009年學術文章

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2009年學術文章

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name

TMEM16 proteins produce volume ...... duced in mice lacking TMEM16A.

@en

TMEM16 proteins produce volume ...... duced in mice lacking TMEM16A.

@nl

type

label

TMEM16 proteins produce volume ...... duced in mice lacking TMEM16A.

@en

TMEM16 proteins produce volume ...... duced in mice lacking TMEM16A.

@nl

prefLabel

TMEM16 proteins produce volume ...... duced in mice lacking TMEM16A.

@en

TMEM16 proteins produce volume ...... duced in mice lacking TMEM16A.

@nl

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JBC.M109.010074

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Journal of Biological Chemistry

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TMEM16 proteins produce volume ...... educed in mice lacking TMEM16A

@en

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Brian D Harfe

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Fadi Aldehni

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Jason R Rock

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Jiraporn Ousingsawat

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Patthara Kongsuphol

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Rainer Schreiber

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Yuemin Tian

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P2860

Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier.

TMEM16B induces chloride currents activated by calcium in mammalian cells

The transmembrane protein TMEM16A is required for normal development of the murine trachea

TMEM16A confers receptor-activated calcium-dependent chloride conductance

Expression cloning of TMEM16A as a calcium-activated chloride channel subunit.

Impaired cell volume regulation in intestinal crypt epithelia of cystic fibrosis mice

Intracellular signalling involved in volume regulatory decrease.

Cell volume in the regulation of cell proliferation and apoptotic cell death.

Molecular structure and physiological function of chloride channels.

Molecular and functional aspects of anionic channels activated during regulatory volume decrease in mammalian cells.

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42

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284

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Karl Kunzelmann

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19654323

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