Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. - Wikidata - awgldk - TriplyDB

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

http://www.wikidata.org/entity/Q39821362

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The nuclear envelopathies and human diseases A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei Epigenetic alterations in aging Role of Intermediate Filaments in Vesicular Traffic When lamins go bad: nuclear structure and disease Nuclear lamins and oxidative stress in cell proliferation and longevity Lamina-associated polypeptide (LAP)2α and other LEM proteins in cancer biology Physiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear Edge Aging and radiation: bad companions The hallmarks of aging A dual role for A-type lamins in DNA double-strand break repair TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends A novel family of plant nuclear envelope-associated proteins.C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2 3D imaging of telomeres and nuclear architecture: An emerging tool of 3D nano-morphology-based diagnosis.DNA damage and lamins Mitotic defects lead to pervasive aneuploidy and accompany loss of RB1 activity in mouse LmnaDhe dermal fibroblasts Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence.Nuclear lamins.The role of DNA damage in laminopathy progeroid syndromes.The nuclear envelope environment and its cancer connections.DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome.Methods to Monitor DNA Repair Defects and Genomic Instability in the Context of a Disrupted Nuclear Lamina.LINC complexes in health and disease.Cell biology of mitotic recombination.Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites The nuclear envelope in genome organization, expression and stability.The role of nuclear lamin B1 in cell proliferation and senescence.Aging genetics and aging.Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation.Lamins at a glance.Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria.Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response Stress-induced release of Oct-1 from the nuclear envelope is mediated by JNK phosphorylation of lamin B1.Influences of lamin A levels on induction of pluripotent stem cells.Lamins in development, tissue maintenance and stress.Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus.Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells.Nuclear lamin functions and disease.

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Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

http://www.wikidata.org/entity/Q39821362

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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name

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

@en

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

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type

label

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

@en

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

@nl

prefLabel

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

@en

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

@nl

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The EMBO Journal

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Novel roles for A-type lamins in telomere biology and the DNA damage response pathway

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Abena B Redwood

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Barry P Sleckman

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Bart Vermolen

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Colin L Stewart

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Daniel Lichtensztejin

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David A Grotsky

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Eric J Gapud

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Ignacio Gonzalez-Suarez

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Lucia Morgado-Palacin

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Stephanie M Perkins

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P2860

Nuclear lamins: building blocks of nuclear architecture

Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins

Control of human telomere length by TRF1 and TRF2

Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy

Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy

Lamin A-dependent nuclear defects in human aging

The three-dimensional organization of telomeres in the nucleus of mammalian cells

Role for perinuclear chromosome tethering in maintenance of genome stability.

Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region.

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2414-2427

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10.1038/EMBOJ.2009.196

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19629036

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