Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.
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Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanomaTranslating Treg Therapy in Humanized MicePrognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysisTregs in infection and vaccinology: heroes or traitors?Galectin-1 research in T cell immunity: past, present and futureFrom tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumorsRegulatory T cell: a protection for tumour cellsImmune modulation of the tumor microenvironment for enhancing cancer immunotherapyMonitoring of the Immune Dysfunction in Cancer PatientsImpaired gp100-Specific CD8(+) T-Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma ModelRational combinations of immunotherapeutics that target discrete pathways.The "Trojan Horse" approach to tumor immunotherapy: targeting the tumor microenvironment.Primary human macrophages serve as vehicles for vaccinia virus replication and dissemination.TLR2-dependent induction of IL-10 and Foxp3+ CD25+ CD4+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo.Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen.Targeting regulatory T cells to improve vaccine immunogenicity in early life.SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γOptimal isolation of functional Foxp3+ induced regulatory T cells using DEREG mice.Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice.Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth.Lineage stability and phenotypic plasticity of Foxp3⁺ regulatory T cells.GARP is regulated by miRNAs and controls latent TGF-β1 production by human regulatory T cells.The TLR7 agonist induces tumor regression both by promoting CD4⁺T cells proliferation and by reversing T regulatory cell-mediated suppression via dendritic cells.Beyond adjuvants: immunomodulation strategies to enhance T cell immunityThe pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cellsImmune escape to PD-L1/PD-1 blockade: seven steps to success (or failure).Regulatory T cells in the bone marrow microenvironment in patients with prostate cancerAntigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regressionLayers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity.The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists.Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells.The interaction between murine melanoma and the immune system reveals that prolonged responses predispose for autoimmunity.Antigen choice determines vaccine-induced generation of immunogenic versus tolerogenic dendritic cells that are marked by differential expression of pancreatic enzymes.Construction and Production of Foxp3-Fc (IgG) DNA Vaccine/Fusion ProteinLow-dose temozolomide before dendritic-cell vaccination reduces (specifically) CD4+CD25++Foxp3+ regulatory T-cells in advanced melanoma patients.Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma.Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion.Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy.Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammationRegulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation.
P2860
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P2860
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Selective depletion of Foxp3+ ...... against established melanoma.
@en
Selective depletion of Foxp3+ ...... against established melanoma.
@nl
type
label
Selective depletion of Foxp3+ ...... against established melanoma.
@en
Selective depletion of Foxp3+ ...... against established melanoma.
@nl
prefLabel
Selective depletion of Foxp3+ ...... against established melanoma.
@en
Selective depletion of Foxp3+ ...... against established melanoma.
@nl
P2093
P50
P1433
P1476
Selective depletion of Foxp3+ ...... against established melanoma.
@en
P2093
Christian T Mayer
Jochen Huehn
Katharina Lahl
Katjana Klages
Michele W L Teng
Shin Foong Ngiow
Tim Sparwasser
P304
P356
10.1158/0008-5472.CAN-10-1736
P407
P577
2010-10-05T00:00:00Z