Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin.
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Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machineryThe multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic targetKATs in cancer: functions and therapiesProtein lysine acetylation by p300/CBPStructure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its AnaloguesEpigenetic modulators as therapeutic targets in prostate cancerAnticancer compound plumbagin and its molecular targets: a structural insight into the inhibitory mechanisms using computational approachesVirtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitorWriters and readers of histone acetylation: structure, mechanism, and inhibitionAcetylation of the proto-oncogene EVI1 abrogates Bcl-xL promoter binding and induces apoptosisPlumbagin promotes the generation of astrocytes from rat spinal cord neural progenitors via activation of the transcription factor Stat3.Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates.A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication.Epigenetic changes induced by curcumin and other natural compounds.Histone acetyltransferases: Rising ancient counterparts to protein kinases.Cytotoxicity of naphthoquinones and their capacity to generate reactive oxygen species is quenched when conjugated with gold nanoparticles.Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), isolated from Plumbago zeylanica, inhibits ultraviolet radiation-induced development of squamous cell carcinomas.Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of RANKL signalingTargeting of histone acetyltransferase p300 by cyclopentenone prostaglandin Δ(12)-PGJ(2) through covalent binding to Cys(1438)Posttranslational Regulation of Human DNA Polymerase ι.Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cells in vivoLive-cell studies of p300/CBP histone acetyltransferase activity and inhibitionInhibition of p300 lysine acetyltransferase activity by luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model.Lysine deacetylase inhibition promotes relaxation of arterial tone and C-terminal acetylation of HSPB6 (Hsp20) in vascular smooth muscle cellsNaphthoquinone-mediated inhibition of lysine acetyltransferase KAT3B/p300, basis for non-toxic inhibitor synthesis.Chemical biology of histone acetyltransferase natural compounds modulators.Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.Histone modifications: Targeting head and neck cancer stem cells.Identification of structural features of 2-alkylidene-1,3-dicarbonyl derivatives that induce inhibition and/or activation of histone acetyltransferases KAT3B/p300 and KAT2B/PCAF.A chemical probe toolbox for dissecting the cancer epigenome.Plumbagin, a medicinal plant (Plumbago zeylanica)-derived 1,4-naphthoquinone, inhibits growth and metastasis of human prostate cancer PC-3M-luciferase cells in an orthotopic xenograft mouse model.Structure-Activity Relationships on Cinnamoyl Derivatives as Inhibitors of p300 Histone Acetyltransferase.Plumbagin exhibits an anti-proliferative effect in human osteosarcoma cells by downregulating FHL2 and interfering with Wnt/β-catenin signalling.Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-Didehydroxyisogarcinol and (±)-6,30-epi-Garcimultiflorone A Utilizing Highly Diastereoselective, Lewis Acid-Controlled Cyclizations.Structure activity relationship of plumbagin in BRCA1 related cancer cells.Epigenetic Modifications in Neurological Diseases: Natural Products as Epigenetic Modulators a Treatment Strategy.Large-scale identification of lysine acetylated proteins in vegetative hyphae of the rice blast fungus.Dissociable roles for histone acetyltransferases p300 and PCAF in hippocampus and perirhinal cortex-mediated object memory.Quinoline-Based p300 Histone Acetyltransferase Inhibitors with Pro-apoptotic Activity in Human Leukemia U937 Cells
P2860
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P2860
Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
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2009年學術文章
@zh-hant
name
Inhibition of lysine acetyltra ...... roxynaphthoquinone, plumbagin.
@en
Inhibition of lysine acetyltra ...... roxynaphthoquinone, plumbagin.
@nl
type
label
Inhibition of lysine acetyltra ...... roxynaphthoquinone, plumbagin.
@en
Inhibition of lysine acetyltra ...... roxynaphthoquinone, plumbagin.
@nl
prefLabel
Inhibition of lysine acetyltra ...... roxynaphthoquinone, plumbagin.
@en
Inhibition of lysine acetyltra ...... roxynaphthoquinone, plumbagin.
@nl
P2093
P2860
P356
P1476
Inhibition of lysine acetyltra ...... roxynaphthoquinone, plumbagin.
@en
P2093
B A Ashok Reddy
B Ruthrotha Selvi
Dipak Dasgupta
Gali R Thanuja
Kodihalli C Ravindra
Mohammed Arif
Natesh Nagashayana
Shipra Agrawal
Suman Kalyan Pradhan
Tapas K Kundu
P2860
P304
24453-24464
P356
10.1074/JBC.M109.023861
P407
P577
2009-07-01T00:00:00Z