Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin. - Wikidata - awgldk - TriplyDB

Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin.

Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin.

http://www.wikidata.org/entity/Q39830457

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Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target KATs in cancer: functions and therapies Protein lysine acetylation by p300/CBP Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues Epigenetic modulators as therapeutic targets in prostate cancer Anticancer compound plumbagin and its molecular targets: a structural insight into the inhibitory mechanisms using computational approaches Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor Writers and readers of histone acetylation: structure, mechanism, and inhibition Acetylation of the proto-oncogene EVI1 abrogates Bcl-xL promoter binding and induces apoptosis Plumbagin promotes the generation of astrocytes from rat spinal cord neural progenitors via activation of the transcription factor Stat3.Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates.A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication.Epigenetic changes induced by curcumin and other natural compounds.Histone acetyltransferases: Rising ancient counterparts to protein kinases.Cytotoxicity of naphthoquinones and their capacity to generate reactive oxygen species is quenched when conjugated with gold nanoparticles.Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), isolated from Plumbago zeylanica, inhibits ultraviolet radiation-induced development of squamous cell carcinomas.Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of RANKL signaling Targeting of histone acetyltransferase p300 by cyclopentenone prostaglandin Δ(12)-PGJ(2) through covalent binding to Cys(1438)Posttranslational Regulation of Human DNA Polymerase ι.Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cells in vivo Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition Inhibition of p300 lysine acetyltransferase activity by luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model.Lysine deacetylase inhibition promotes relaxation of arterial tone and C-terminal acetylation of HSPB6 (Hsp20) in vascular smooth muscle cells Naphthoquinone-mediated inhibition of lysine acetyltransferase KAT3B/p300, basis for non-toxic inhibitor synthesis.Chemical biology of histone acetyltransferase natural compounds modulators.Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.Histone modifications: Targeting head and neck cancer stem cells.Identification of structural features of 2-alkylidene-1,3-dicarbonyl derivatives that induce inhibition and/or activation of histone acetyltransferases KAT3B/p300 and KAT2B/PCAF.A chemical probe toolbox for dissecting the cancer epigenome.Plumbagin, a medicinal plant (Plumbago zeylanica)-derived 1,4-naphthoquinone, inhibits growth and metastasis of human prostate cancer PC-3M-luciferase cells in an orthotopic xenograft mouse model.Structure-Activity Relationships on Cinnamoyl Derivatives as Inhibitors of p300 Histone Acetyltransferase.Plumbagin exhibits an anti-proliferative effect in human osteosarcoma cells by downregulating FHL2 and interfering with Wnt/β-catenin signalling.Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-Didehydroxyisogarcinol and (±)-6,30-epi-Garcimultiflorone A Utilizing Highly Diastereoselective, Lewis Acid-Controlled Cyclizations.Structure activity relationship of plumbagin in BRCA1 related cancer cells.Epigenetic Modifications in Neurological Diseases: Natural Products as Epigenetic Modulators a Treatment Strategy.Large-scale identification of lysine acetylated proteins in vegetative hyphae of the rice blast fungus.Dissociable roles for histone acetyltransferases p300 and PCAF in hippocampus and perirhinal cortex-mediated object memory.Quinoline-Based p300 Histone Acetyltransferase Inhibitors with Pro-apoptotic Activity in Human Leukemia U937 Cells

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P2860

Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin.

http://www.wikidata.org/entity/Q39830457

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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name

Inhibition of lysine acetyltra ...... roxynaphthoquinone, plumbagin.

@en

Inhibition of lysine acetyltra ...... roxynaphthoquinone, plumbagin.

@nl

type

label

Inhibition of lysine acetyltra ...... roxynaphthoquinone, plumbagin.

@en

Inhibition of lysine acetyltra ...... roxynaphthoquinone, plumbagin.

@nl

prefLabel

Inhibition of lysine acetyltra ...... roxynaphthoquinone, plumbagin.

@en

Inhibition of lysine acetyltra ...... roxynaphthoquinone, plumbagin.

@nl

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JBC.M109.023861

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Journal of Biological Chemistry

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Inhibition of lysine acetyltra ...... roxynaphthoquinone, plumbagin.

@en

P2093

B A Ashok Reddy

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B Ruthrotha Selvi

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Dipak Dasgupta

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Gali R Thanuja

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Kodihalli C Ravindra

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Mohammed Arif

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Natesh Nagashayana

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Shipra Agrawal

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Suman Kalyan Pradhan

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Tapas K Kundu

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P2860

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

CBP/p300 in cell growth, transformation, and development

The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin

Histone acetyltransferases

DNA damage activates p53 through a phosphorylation-acetylation cascade

p300/CBP proteins: HATs for transcriptional bridges and scaffolds

Histone acetyltransferase complexes.

p300 and CBP: partners for life and death.

p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels.

HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.

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24453-24464

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scholarly article

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10.1074/JBC.M109.023861

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36

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P478

284

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2009-07-01T00:00:00Z

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19570987

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2782038

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