Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. - Wikidata - awgldk - TriplyDB

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes.

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes.

http://www.wikidata.org/entity/Q39832812

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The emerging chondrocyte channelome Tendon mechanobiology: Current knowledge and future research opportunities Biomechanical factors in osteoarthritis Genetically targeted magnetic control of the nervous system TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye.Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis Potassium channels in articular chondrocytes Expression of Transient Receptor Potential Vanilloid (TRPV) channels in different passages of articular chondrocytes Characterization of a stretch-activated potassium channel in chondrocytes Promoting increased mechanical properties of tissue engineered neocartilage via the application of hyperosmolarity and 4α-phorbol 12,13-didecanoate (4αPDD)Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.Chondrocyte channel transcriptomics: do microarray data fit with expression and functional data?Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations.Integrin α1β1 participates in chondrocyte transduction of osmotic stress Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation The mechanobiology of articular cartilage: bearing the burden of osteoarthritis.Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice.Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.Osmolarity influences chondrocyte repair after injury in human articular cartilage.Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton Temperature changes and chondrocyte death during drilling in a bovine cartilage model and chondroprotection by modified irrigation solutions.TRPV4 as a therapeutic target for joint diseases.TRPV4 and K(Ca) ion channels functionally couple as osmosensors in the paraventricular nucleus Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage Inhibition of T-Type Voltage Sensitive Calcium Channel Reduces Load-Induced OA in Mice and Suppresses the Catabolic Effect of Bone Mechanical Stress on Chondrocytes Polymodal Transient Receptor Potential Vanilloid (TRPV) Ion Channels in Chondrogenic Cells Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress.The postnatal role of Sox9 in cartilage.Diurnal variations in articular cartilage thickness and strain in the human knee.TRPV4 channel activation improves the tensile properties of self-assembled articular cartilage constructs.Unraveling the mechanism by which TRPV4 mutations cause skeletal dysplasias.Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.Mechanobiology of TGFβ signaling in the skeleton.Mechanical regulation of chondrogenesis.Transplantation of Scaffold-Free Cartilage-Like Cell-Sheets Made from Human Bone Marrow Mesenchymal Stem Cells for Cartilage Repair: A Preclinical Study.

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P2860

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes.

http://www.wikidata.org/entity/Q39832812

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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Functional characterization of ...... orcine articular chondrocytes.

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Functional characterization of ...... orcine articular chondrocytes.

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Functional characterization of ...... orcine articular chondrocytes.

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Functional characterization of ...... orcine articular chondrocytes.

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Functional characterization of ...... orcine articular chondrocytes.

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Functional characterization of ...... orcine articular chondrocytes.

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Arthritis & Rheumatology

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Functional characterization of ...... orcine articular chondrocytes.

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Bartholomew J Votta

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Dana S Levy

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David B Lipshutz

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Holly A Leddy

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Mimi N Phan

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Sanjay Kumar

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Suk Hee Lee

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Wolfgang Liedtke

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P2860

OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity

Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site

Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor

THE CHONDROCYTE: A CELL UNDER PRESSURE

Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism.

Abnormal osmotic regulation in trpv4-/- mice.

Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways.

Hypo-osmotic stress induces calcium-dependent actin reorganization in articular chondrocytes.

The extracellular matrix, interstitial fluid and ions as a mechanical signal transducer in articular cartilage.

Calcium as a versatile second messenger in the control of gene expression.

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10.1002/ART.24799

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2846816

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