Importance of drug enantiomers in clinical pharmacology.
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The alpha- and beta-adrenoceptor blocking activities of labetalol and its RR-SR (50:50) stereoisomersDetermination of Ibuprofen in human plasma by high-performance liquid chromatography: validation and application in pharmacokinetic study.Chiral resolution of flurbiprofen and ketoprofen enantiomers by HPLC on a glycopeptide-type column chiral stationary phase.Quantitation of the enantiomers of rimantadine and its hydroxylated metabolites in human plasma by gas chromatography/mass spectrometry.Chiral separation by high performance liquid chromatography. I. Review on indirect separation of enantiomers as diastereomeric derivatives using ultraviolet, fluorescence and electrochemical detection.Stereoselective metabolism of the monoterpene carvone by rat and human liver microsomes.Development and validation of an enantioselective LC-MS/MS method to quantify enantiomers of (±)-TAK-700 in rat plasma: lack of in vivo inversion of (+)-TAK-700 (Orteronel) to its antipode.Clinical pharmacology through the looking glass: reflections on the racemate vs enantiomer debate.Use of pseudoracemic nitrendipine to elucidate the metabolic steps responsible for stereoselective disposition of nitrendipine enantiomersSedation and histamine H1-receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindeneValidation of an enantioselective LC-MS/MS method to quantify enantiomers of (±)-OTX015 in mice plasma: Lack of in vivo inversion of (-)-OTX015 to its antipode.A rapid and efficient analytical method for the quantification of a novel anticholinergic compound, R-phencynonate, by stable isotope-dilution LC-MS/MS and its application to bioavailability and dose proportionality studies.Stereoselective drug disposition: potential for misinterpretation of drug disposition data.Stereoselectivity in drug metabolism.An Enantiomer of an Oral Small-Molecule TSH Receptor Agonist Exhibits Improved Pharmacologic Properties.Stereoselective pharmacokinetics of ifosfamide in male and female rats.Chirality and anaesthetic drugs: A review and an update.Effect of chirality on cellular uptake, imaging and photodynamic therapy of photosensitizers derived from chlorophyll-aPractical clinical pharmacology: drug handling and responseAbsolute configuration of beer's bitter compounds.Stereochemical aspects of pharmacotherapy.(S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats.Percutaneous absorption of the montoterperne carvone: implication of stereoselective metabolism on blood levels.Pharmacokinetic interactions of cefprozil with food, propantheline, metoclopramide, and probenecid in healthy volunteers.Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves.Tensor algebra-based geometric methodology to codify central chirality on organic molecules.Chirality and neuropsychiatric drugs: an update on stereoselective disposition and clinical pharmacokinetics of bupropion.Simple Isocratic HPLC Method for Determination of Enantiomeric Impurity in Besifloxacin Hydrochloride.Tissue distribution of mexiletine enantiomers in rats.Human pharmacokinetics and interconversion of enantiomers of MK-0767, a dual PPARalpha/gamma agonist.A dispersive liquid-liquid microextraction and chiral separation of carvedilol in human plasma using capillary electrophoresis.The pharmacokinetics of pimobendan enantiomers after oral and intravenous administration of racemate pimobendan formulations in healthy dogs.The stereoselectivity of the 'single drug binding site' of human alpha 1-acid glycoprotein (orosomucoid).Dose proportionality of bisoprolol enantiomers in humans after oral administration of the racemate.
P2860
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P2860
Importance of drug enantiomers in clinical pharmacology.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh
1985年學術文章
@zh-hant
name
Importance of drug enantiomers in clinical pharmacology.
@en
Importance of drug enantiomers in clinical pharmacology.
@nl
type
label
Importance of drug enantiomers in clinical pharmacology.
@en
Importance of drug enantiomers in clinical pharmacology.
@nl
prefLabel
Importance of drug enantiomers in clinical pharmacology.
@en
Importance of drug enantiomers in clinical pharmacology.
@nl
P1433
P1476
Importance of drug enantiomers in clinical pharmacology.
@en
P2093
P304
P356
10.2165/00003495-198530040-00003
P577
1985-10-01T00:00:00Z
P6179
1023180561