Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation.
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The structural biology of Toll-like receptorsRNA mediated Toll-like receptor stimulation in health and diseaseCrystal structure of the C-terminal domain of mouse TLR9Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.Expression analysis of turkey (Meleagris gallopavo) toll-like receptors and molecular characterization of avian specific TLR15.A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness.Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events.Single molecule in vivo analysis of toll-like receptor 9 and CpG DNA interaction.Direct measurement of the interaction force between immunostimulatory CpG-DNA and TLR9 fusion protein.TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis.Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology.Negative self-regulation of TLR9 signaling by its N-terminal proteolytic cleavage productEmerging principles governing signal transduction by pattern-recognition receptorsToll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response.Traditional biochemical assays for studying toll-like receptor 9.Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling.Heterozygous carriage of a dysfunctional Toll-like receptor 9 allele affects CpG oligonucleotide responses in B cells.Leucine-rich repeat 11 of Toll-like receptor 9 can tightly bind to CpG-containing oligodeoxynucleotides, and the positively charged residues are critical for the high affinity.Synthetic Human TLR9-LRR11 Peptide Attenuates TLR9 Signaling by Binding to and thus Decreasing Internalization of CpG Oligodeoxynucleotides.Toll-like receptor 9 interaction with CpG ODN--an in silico analysis approachSelectively targeting the toll-like receptor 9 (TLR9)--IRF 7 signaling pathway by polymer blend particlesA novel small-molecule enantiomeric analogue of traditional (-)-morphinans has specific TLR9 antagonist properties and reduces sterile inflammation-induced organ damage.Modulating toll-like receptor 7 and 9 responses as therapy for allergy and autoimmunity.Recognition of bacterial infection by innate immune sensors.Structural basis of innate immune recognition of viral RNA.Immunotherapeutic potential of CpG oligodeoxynucleotides in veterinary species.Trafficking of endosomal Toll-like receptors.Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors.Toll-like receptor signaling pathways.DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature.New vistas on TLR9 activation.Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9.Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology.Structural aspects of nucleic acid-sensing Toll-like receptors.Toward a structural understanding of nucleic acid-sensing Toll-like receptors in the innate immune system.Comprehensive modeling and functional analysis of Toll-like receptor ligand-recognition domains.In silico analysis of human Toll-like receptor 7 ligand binding domain.
P2860
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P2860
Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Identification of an N-termina ...... -mediated receptor activation.
@en
Identification of an N-termina ...... -mediated receptor activation.
@nl
type
label
Identification of an N-termina ...... -mediated receptor activation.
@en
Identification of an N-termina ...... -mediated receptor activation.
@nl
prefLabel
Identification of an N-termina ...... -mediated receptor activation.
@en
Identification of an N-termina ...... -mediated receptor activation.
@nl
P2093
P356
P1476
Identification of an N-termina ...... -mediated receptor activation.
@en
P2093
Alexander H Dalpke
Alexander N R Weber
Andriy V Kubarenko
Mirjam E Peter
P304
P356
10.4049/JIMMUNOL.0900819
P407
P577
2009-06-01T00:00:00Z