A Gly145Ser substitution in the transcriptional activator PrfA causes constitutive overexpression of virulence factors in Listeria monocytogenes.
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Examination of Listeria monocytogenes intracellular gene expression by using the green fluorescent protein of Aequorea victoriaListeria monocytogenes - from saprophyte to intracellular pathogenAllosteric mutants show that PrfA activation is dispensable for vacuole escape but required for efficient spread and Listeria survival in vivoThe mutation G145S in PrfA, a key virulence regulator of Listeria monocytogenes, increases DNA-binding affinity by stabilizing the HTH motif.Identification of Listeria monocytogenes genes contributing to intracellular replication by expression profiling and mutant screening.Influence of sublethal concentrations of common disinfectants on expression of virulence genes in Listeria monocytogenes.A homolog of CcpA mediates catabolite control in Listeria monocytogenes but not carbon source regulation of virulence genes.Regulation of hly expression in Listeria monocytogenes by carbon sources and pH occurs through separate mechanisms mediated by PrfA.Pleiotropic enhancement of bacterial pathogenesis resulting from the constitutive activation of the Listeria monocytogenes regulatory factor PrfA.Constitutive activation of PrfA tilts the balance of Listeria monocytogenes fitness towards life within the host versus environmental survivalHpt, a bacterial homolog of the microsomal glucose- 6-phosphate translocase, mediates rapid intracellular proliferation in Listeria.Listeria pathogenesis and molecular virulence determinantsSequence variations within PrfA DNA binding sites and effects on Listeria monocytogenes virulence gene expression.Probing the role of protein surface charge in the activation of PrfA, the central regulator of Listeria monocytogenes pathogenesis.Expression of listeriolysin O and ActA by intracellular and extracellular Listeria monocytogenes.The LisRK signal transduction system determines the sensitivity of Listeria monocytogenes to nisin and cephalosporins.Intracellular induction of Listeria monocytogenes actA expressionInhibition of calpain blocks the phagosomal escape of Listeria monocytogenes.Listeria monocytogenes PrsA2 is required for virulence factor secretion and bacterial viability within the host cell cytosol.13C isotopologue perturbation studies of Listeria monocytogenes carbon metabolism and its modulation by the virulence regulator PrfADirected antigen delivery as a vaccine strategy for an intracellular bacterial pathogen.How the bacterial pathogen Listeria monocytogenes mediates the switch from environmental Dr. Jekyll to pathogenic Mr. HydeOverexpression of PrfA leads to growth inhibition of Listeria monocytogenes in glucose-containing culture media by interfering with glucose uptakeRoles of a novel Crp/Fnr family transcription factor Lmo0753 in soil survival, biofilm production and surface attachment to fresh produce of Listeria monocytogenes.Glutathione activates virulence gene expression of an intracellular pathogen.The metabolic regulator CodY links Listeria monocytogenes metabolism to virulence by directly activating the virulence regulatory gene prfA.Species-specific differences in the activity of PrfA, the key regulator of listerial virulence genesIdentification of a peptide-pheromone that enhances Listeria monocytogenes escape from host cell vacuoles.Association of ActA to peptidoglycan revealed by cell wall proteomics of intracellular Listeria monocytogenesConstitutive expression of fibronectin binding in Streptococcus pyogenes as a result of anaerobic activation of rofA.A novel C-terminal mutation resulting in constitutive activation of the Listeria monocytogenes central virulence regulatory factor PrfA.An In Vivo Selection Identifies Listeria monocytogenes Genes Required to Sense the Intracellular Environment and Activate Virulence Factor Expression.Identification of novel Listeria monocytogenes secreted virulence factors following mutational activation of the central virulence regulator, PrfA.Optimizing the balance between host and environmental survival skills: lessons learned from Listeria monocytogenes.Metabolic Genetic Screens Reveal Multidimensional Regulation of Virulence Gene Expression in Listeria monocytogenes and an Aminopeptidase That Is Critical for PrfA Protein Activation.Requirement of the Listeria monocytogenes broad-range phospholipase PC-PLC during infection of human epithelial cells.A Dual Microscopy-Based Assay To Assess Listeria monocytogenes Cellular Entry and Vacuolar Escape.Tools for functional postgenomic analysis of listeria monocytogenes.Constitutive Activation of the PrfA regulon enhances the potency of vaccines based on live-attenuated and killed but metabolically active Listeria monocytogenes strainsSelected prfA* mutations in recombinant attenuated Listeria monocytogenes strains augment expression of foreign immunogens and enhance vaccine-elicited humoral and cellular immune responses.
P2860
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P2860
A Gly145Ser substitution in the transcriptional activator PrfA causes constitutive overexpression of virulence factors in Listeria monocytogenes.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
A Gly145Ser substitution in th ...... ors in Listeria monocytogenes.
@en
A Gly145Ser substitution in th ...... ors in Listeria monocytogenes.
@nl
type
label
A Gly145Ser substitution in th ...... ors in Listeria monocytogenes.
@en
A Gly145Ser substitution in th ...... ors in Listeria monocytogenes.
@nl
prefLabel
A Gly145Ser substitution in th ...... ors in Listeria monocytogenes.
@en
A Gly145Ser substitution in th ...... ors in Listeria monocytogenes.
@nl
P2093
P2860
P1476
A Gly145Ser substitution in th ...... ors in Listeria monocytogenes.
@en
P2093
Domínguez-Bernal G
Vazquez-Boland JA
P2860
P304
P356
10.1128/JB.179.5.1533-1540.1997
P577
1997-03-01T00:00:00Z