Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation.
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Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cellsGenomic diversity of colorectal cancer: Changing landscape and emerging targetsCDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction pointcAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.Inhibition of mTORC1 signaling reduces tumor growth but does not prevent cancer progression in a mouse model of thyroid cancer.A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.Emerging insights into the molecular and cellular basis of glioblastoma.The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes.Neurotensin signaling stimulates glioblastoma cell proliferation by upregulating c-Myc and inhibiting miR-29b-1 and miR-129-3pDifferential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.Knockdown of NEAT1 restrained the malignant progression of glioma stem cells by activating microRNA let-7e.Physiopathology of somatolactotroph cells: from transduction mechanisms to cotargeting therapy.CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis.Sensitivity of glioblastomas to clinically available MEK inhibitors is defined by neurofibromin 1 deficiencyJNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21.CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib.Statins induce apoptosis through inhibition of Ras signaling pathways and enhancement of Bim and p27 expression in human hematopoietic tumor cells.CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6Translationally controlled tumour protein is associated with podocyte hypertrophy in a mouse model of type 1 diabetes.
P2860
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P2860
Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Combined inhibition of MEK and ...... prevents their proliferation.
@en
Combined inhibition of MEK and ...... prevents their proliferation.
@nl
type
label
Combined inhibition of MEK and ...... prevents their proliferation.
@en
Combined inhibition of MEK and ...... prevents their proliferation.
@nl
prefLabel
Combined inhibition of MEK and ...... prevents their proliferation.
@en
Combined inhibition of MEK and ...... prevents their proliferation.
@nl
P1433
P1476
Combined inhibition of MEK and ...... prevents their proliferation.
@en
P2093
Pierre P Roger
Sabine Paternot
P304
P356
10.1158/0008-5472.CAN-08-3260
P407
P577
2009-05-19T00:00:00Z