siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells.
about
Cancer cells acquire mitotic drug resistance properties through beta I-tubulin mutations and alterations in the expression of beta-tubulin isotypesHtrA1 sensitizes ovarian cancer cells to cisplatin-induced cytotoxicity by targeting XIAP for degradation.The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro.New clinically relevant, orthotopic mouse models of human chondrosarcoma with spontaneous metastasisADAM15 exerts an antiapoptotic effect on osteoarthritic chondrocytes via up-regulation of the X-linked inhibitor of apoptosis.GDC-0449 in patients with advanced chondrosarcomas: a French Sarcoma Group/US and French National Cancer Institute Single-Arm Phase II Collaborative Study.Therapeutic molecular targets in human chondrosarcoma.Surmounting chemotherapy and radioresistance in chondrosarcoma: molecular mechanisms and therapeutic targets.Recent attempts at RNAi-mediated P-glycoprotein downregulation for reversal of multidrug resistance in cancer.Chondrosarcoma of the hyoid bone: case report and review of current management options.miR-125b acts as a tumor suppressor in chondrosarcoma cells by the sensitization to doxorubicin through direct targeting the ErbB2-regulated glucose metabolism.Real-time monitoring of cisplatin cytotoxicity on three-dimensional spheroid tumor cells.An orthotopic mouse model for chondrosarcoma of bone provides an in vivo tool for drug testing.Combination effect of PectaSol and Doxorubicin on viability, cell cycle arrest and apoptosis in DU-145 and LNCaP prostate cancer cell lines.Simultaneous targeting of P-gp and XIAP with siRNAs increases sensitivity of P-gp overexpressing CML cells to imatinib.Lysosomal drug sequestration as a mechanism of drug resistance in vascular sarcoma cells marked by high CSF-1R expression.rAAV Vectors as Safe and Efficient Tools for the Stable Delivery of Genes to Primary Human Chondrosarcoma Cells In Vitro and In Situ.Inhibition of novel GCN5-ATM axis restricts the onset of acquired drug resistance in leukemia.Doxorubicin-conjugated dexamethasone induced MCF-7 apoptosis without entering the nucleus and able to overcome MDR-1-induced resistance
P2860
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P2860
siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
siRNA-based targeting of antia ...... pressing chondrosarcoma cells.
@en
siRNA-based targeting of antia ...... pressing chondrosarcoma cells.
@nl
type
label
siRNA-based targeting of antia ...... pressing chondrosarcoma cells.
@en
siRNA-based targeting of antia ...... pressing chondrosarcoma cells.
@nl
prefLabel
siRNA-based targeting of antia ...... pressing chondrosarcoma cells.
@en
siRNA-based targeting of antia ...... pressing chondrosarcoma cells.
@nl
P2093
P2860
P356
P1433
P1476
siRNA-based targeting of antia ...... pressing chondrosarcoma cells.
@en
P2093
Dae Won Kim
Francis Y Lee
Jung Hee Ha
Kyung-Ok Kim
Mike J Shin
Sung Wook Seo
P2860
P2888
P356
10.1186/1476-4598-8-28
P577
2009-05-15T00:00:00Z
P5875
P6179
1014152015