Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides.
about
Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne MetathesisBicyclic Peptides as Next-Generation Therapeutics.High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation.New Modalities for Challenging Targets in Drug Discovery.Stapled peptides: providing the best of both worlds in drug development.A remote C-C bond cleavage-enabled skeletal reorganization: Access to medium-/large-sized cyclic alkenes.Formation of paramagnetic metallacyclobutadienes by reaction of diaminoacetylenes with molybdenum alkylidyne complexes.Alkyne Metathesis with Silica-Supported and Molecular Catalysts at Parts-per-Million Loadings.Engineering an Affinity-Enhanced Peptide through Optimization of Cyclization Chemistry.An intramolecular tryptophan-condensation approach for peptide stapling.Peptide Macrocycles Developed from Precisely Regulated Multiple Cyclization of Unprotected Peptides.High Oxidation State Molybdenum N-Heterocyclic Carbene Alkylidyne Complexes: Synthesis, Mechanistic Studies, and Reactivity.Adapting the Glaser Reaction for Bioconjugation: Robust Access to Structurally Simple, Rigid Linkers.Diversity-Oriented Synthesis of Cyclic Azapeptides by A3 -Macrocyclization Provides High-Affinity CD36-Modulating Peptidomimetics.A precisely positioned chiral center in an i, i + 7 tether modulates the helicity of the backbone peptide.
P2860
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P2860
Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh
2016年學術文章
@zh-hant
name
Orthogonal ring-closing alkyne ...... e-targeting bicyclic peptides.
@en
Orthogonal ring-closing alkyne ...... e-targeting bicyclic peptides.
@nl
type
label
Orthogonal ring-closing alkyne ...... e-targeting bicyclic peptides.
@en
Orthogonal ring-closing alkyne ...... e-targeting bicyclic peptides.
@nl
prefLabel
Orthogonal ring-closing alkyne ...... e-targeting bicyclic peptides.
@en
Orthogonal ring-closing alkyne ...... e-targeting bicyclic peptides.
@nl
P2860
P50
P356
P1476
Orthogonal ring-closing alkyne ...... e-targeting bicyclic peptides.
@en
P2093
Sebastian Schaubach
P2860
P2888
P356
10.1038/NCOMMS11300
P407
P577
2016-04-14T00:00:00Z
P6179
1037317813