A novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: possible interaction with a species-specific exosite.
about
Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibitionThe major human and mouse granzymes are structurally and functionally divergentReaching the melting point: Degradative enzymes and protease inhibitors involved in baculovirus infection and disseminationDelivery and therapeutic potential of human granzyme B.Death by a thousand cuts: granzyme pathways of programmed cell deathToxoplasma gondii inhibits granzyme B-mediated apoptosis by the inhibition of granzyme B function in host cellsAutoantigens: the critical partner in initiating and propagating systemic autoimmunity.Viral subversion of apoptotic enzymes: escape from death row.Non-apoptotic functions of granzymes.Tethering of eIF4G to adenoviral mRNAs by viral 100k protein drives ribosome shunting.A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage.Non-cytotoxic antiviral activities of granzymes in the context of the immune antiviral state.Faithful chaperones.Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells.Arginine methylation of human adenovirus type 5 L4 100-kilodalton protein is required for efficient virus production.The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains.
P2860
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P2860
A novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: possible interaction with a species-specific exosite.
description
2003 nî lūn-bûn
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name
A novel domain in adenovirus L ...... th a species-specific exosite.
@en
A novel domain in adenovirus L ...... th a species-specific exosite.
@nl
type
label
A novel domain in adenovirus L ...... th a species-specific exosite.
@en
A novel domain in adenovirus L ...... th a species-specific exosite.
@nl
prefLabel
A novel domain in adenovirus L ...... th a species-specific exosite.
@en
A novel domain in adenovirus L ...... th a species-specific exosite.
@nl
P2093
P2860
P1476
A novel domain in adenovirus L ...... th a species-specific exosite.
@en
P2093
Antony Rosen
Felipe Andrade
Livia A Casciola-Rosen
P2860
P304
P356
10.1128/MCB.23.17.6315-6326.2003
P407
P577
2003-09-01T00:00:00Z