Alphavbeta3/alphavbeta5 integrins-FAK-RhoB: a novel pathway for hypoxia regulation in glioblastoma.
about
Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by β8 integrinβ1 Integrins as Therapeutic Targets to Disrupt Hallmarks of CancerFAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing.Integrins in the Spotlight of CancerRNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma.Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia.Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.Normalization of the vasculature for treatment of cancer and other diseases.An engineered knottin peptide labeled with 18F for PET imaging of integrin expression.Tissue-engineered three-dimensional tumor models to study tumor angiogenesis.Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation.Oxygen-controlled three-dimensional cultures to analyze tumor angiogenesisAlternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1α and vascular endothelial growth factor signaling.A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesisECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation.Critical functions of RhoB in support of glioblastoma tumorigenesisInsulin-like growth factor binding protein-3 inhibits cell adhesion via suppression of integrin β4 expression.Immunohistochemical analysis of integrins αvβ3, αvβ5 and α5β1, and their ligands, fibrinogen, fibronectin, osteopontin and vitronectin, in frozen sections of human oral head and neck squamous cell carcinomas.Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts.Fusicoccin a, a phytotoxic carbotricyclic diterpene glucoside of fungal origin, reduces proliferation and invasion of glioblastoma cells by targeting multiple tyrosine kinasesEGFRvIII/integrin β3 interaction in hypoxic and vitronectinenriching microenvironment promote GBM progression and metastasis.Recombinant Osteopontin Stabilizes Smooth Muscle Cell Phenotype via Integrin Receptor/Integrin-Linked Kinase/Rac-1 Pathway After Subarachnoid Hemorrhage in Rats.The effect of alpha-v integrin inhibition on the malignant characteristics of medulloblastoma.Integrin targeted drug and gene delivery.RhoB regulates the function of macrophages in the hypoxia-induced inflammatory response.A model for phospho-caveolin-1-driven turnover of focal adhesions.Influence of stress on extracellular matrix and integrin biology.Targeting of the innate immunity/inflammation as complementary anti-tumor therapies.Narciclasine as well as other Amaryllidaceae isocarbostyrils are promising GTP-ase targeting agents against brain cancers.A novel treatment for glioblastoma: integrin inhibition.The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies.Cilengitide: a prototypic integrin inhibitor for the treatment of glioblastoma and other malignancies.Regulation and dysregulation of astrocyte activation and implications in tumor formation.MicroRNAs and tumor vasculature normalization: impact on anti-tumor immune response.αvβ3, αvβ5 and αvβ6 integrins in brain metastases of lung cancer.Longitudinal expression analysis of αv integrins in human gliomas reveals upregulation of integrin αvβ3 as a negative prognostic factor.Impaired erythropoietin synthesis in chronic kidney disease is caused by alterations in extracellular matrix composition.Insulin-like growth factor binding protein-2 regulates β-catenin signaling pathway in glioma cells and contributes to poor patient prognosis.Plexin-B1 indirectly affects glioma invasiveness and angiogenesis by regulating the RhoA/αvβ3 signaling pathway and SRPK1.
P2860
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P2860
Alphavbeta3/alphavbeta5 integrins-FAK-RhoB: a novel pathway for hypoxia regulation in glioblastoma.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Alphavbeta3/alphavbeta5 integr ...... ia regulation in glioblastoma.
@en
Alphavbeta3/alphavbeta5 integr ...... ia regulation in glioblastoma.
@nl
type
label
Alphavbeta3/alphavbeta5 integr ...... ia regulation in glioblastoma.
@en
Alphavbeta3/alphavbeta5 integr ...... ia regulation in glioblastoma.
@nl
prefLabel
Alphavbeta3/alphavbeta5 integr ...... ia regulation in glioblastoma.
@en
Alphavbeta3/alphavbeta5 integr ...... ia regulation in glioblastoma.
@nl
P2093
P1433
P1476
Alphavbeta3/alphavbeta5 integr ...... ia regulation in glioblastoma.
@en
P2093
Caroline Delmas
Christine Toulas
Gilles Favre
Jacques Bonnet
Nicolas Skuli
Sylvie Monferran
P304
P356
10.1158/0008-5472.CAN-08-2158
P407
P577
2009-04-07T00:00:00Z