Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
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Mechanism for down-regulation of CD28 by Nef.Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activityCo-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulationMechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes.The human polycomb group EED protein interacts with the integrase of human immunodeficiency virus type 1The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrixConformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes.Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.CXCR4 is down-regulated in cells infected with the CD4-independent X4 human immunodeficiency virus type 1 isolate m7NDKHuman immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions.Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum.The HIV-1 gp120 CD4-bound conformation is preferentially targeted by antibody-dependent cellular cytotoxicity-mediating antibodies in sera from HIV-1-infected individualsSlaying the Trojan horse: natural killer cells exhibit robust anti-HIV-1 antibody-dependent activation and cytolysis against allogeneic T cellsCD4 mimetics sensitize HIV-1-infected cells to ADCC.Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cellInhibition of Nef- and phorbol ester-induced CD4 degradation by macrolide antibiotics.Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral proteaseMechanism of human immunodeficiency virus type 1 localization in CD4-negative thymocytes: differentiation from a CD4-positive precursor allows productive infection.Nef proteins encoded by human and simian immunodeficiency viruses induce the accumulation of endosomes and lysosomes in human T cells.Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways.Nef Proteins from HIV-1 Elite Controllers Are Inefficient at Preventing Antibody-Dependent Cellular CytotoxicityHIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication.Lentiviral vectors interfering with virus-induced CD4 down-modulation potently block human immunodeficiency virus type 1 replication in primary lymphocytes.Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity.Human immunodeficiency virus type 1 Nef domains required for disruption of major histocompatibility complex class I trafficking are also necessary for coprecipitation of Nef with HLA-A2.The activity of Nef on HIV-1 infectivityNef of HIV-1 interacts directly with calcium-bound calmodulin.Impaired Downregulation of NKG2D Ligands by Nef Proteins from Elite Controllers Sensitizes HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity.A novel trafficking signal within the HLA-C cytoplasmic tail allows regulated expression upon differentiation of macrophages.HIV Type 1 Nef is released from infected cells in CD45(+) microvesicles and is present in the plasma of HIV-infected individuals.Human immunodeficiency virus type 1 Vpr protein does not modulate surface expression of the CD4 receptor.Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression.Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor.
P2860
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P2860
Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
@en
Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
@nl
type
label
Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
@en
Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
@nl
prefLabel
Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
@en
Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
@nl
P2093
P2860
P1433
P1476
Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
@en
P2093
Dautry-Varsat A
Maréchal V
Schwartz O
P2860
P304
P407
P577
1995-01-01T00:00:00Z