Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway.
about
Targeting mTOR for the treatment of AML. New agents and new directionsPlumbagin inhibits proliferative and inflammatory responses of T cells independent of ROS generation but by modulating intracellular thiolsThe Philadelphia chromosome in leukemogenesisDepolarization Controls TRAIL-Sensitization and Tumor-Selective Killing of Cancer Cells: Crosstalk with ROSDual effect of oxidative stress on leukemia cancer induction and treatmentEltrombopag modulates reactive oxygen species and decreases acute myeloid leukemia cell survivalA novel AHI-1-BCR-ABL-DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy.GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells.H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling.ROS-mediated platelet generation: a microenvironment-dependent manner for megakaryocyte proliferation, differentiation, and maturation.Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia.NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells.New insights into redox homeostasis as a therapeutic target in B-cell malignancies.NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases.Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells.Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events.Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance.Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cellsThe NOX toolbox: validating the role of NADPH oxidases in physiology and disease.Redox control of leukemia: from molecular mechanisms to therapeutic opportunities.The chimeric ubiquitin ligase SH2-U-box inhibits the growth of imatinib-sensitive and resistant CML by targeting the native and T315I-mutant BCR-ABLInhibition of YAP suppresses CML cell proliferation and enhances efficacy of imatinib in vitro and in vivo.Chronic myeloid leukemia cells refractory/resistant to tyrosine kinase inhibitors are genetically unstable and may cause relapse and malignant progression to the terminal disease state.Chronic myeloid leukemia stem cells and developing therapies.Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2.Hydrogen peroxide: a Jekyll and Hyde signalling molecule.AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications.Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.Aiding and abetting roles of NOX oxidases in cellular transformation.Oxidative metabolism in cancer: A STAT affair?ROS signalling, NADPH oxidases and cancer.NF-κB suppresses ROS levels in BCR-ABL(+) cells to prevent activation of JNK and cell death.Inhibition of protein-tyrosine phosphatase 1B (PTP1B) mediates ubiquitination and degradation of Bcr-Abl protein.Novel drug therapies in myeloid leukemia.Deregulated expression of Cdc6 as BCR/ABL-dependent survival factor in chronic myeloid leukemia cells.JAK2V617F mediates resistance to DNA damage-induced apoptosis by modulating FOXO3A localization and Bcl-xL deamidation.NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells.ROS-dependent phosphorylation of Bax by wortmannin sensitizes melanoma cells for TRAIL-induced apoptosis.Approaches for targeting self-renewal pathways in cancer stem cells: implications for hematological treatments.Polymeric delivery of siRNA for dual silencing of Mcl-1 and P-glycoprotein and apoptosis induction in drug-resistant breast cancer cells.
P2860
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P2860
Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway.
@en
Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway.
@nl
type
label
Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway.
@en
Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway.
@nl
prefLabel
Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway.
@en
Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway.
@nl
P2093
P2860
P356
P1433
P1476
Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway.
@en
P2093
P2860
P2888
P304
P356
10.1038/LEU.2009.49
P577
2009-03-19T00:00:00Z
P5875
P6179
1039687124