Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells. - Wikidata - awgldk - TriplyDB

Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.

Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.

http://www.wikidata.org/entity/Q39885727

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Glia and alpha-synuclein in neurodegeneration: A complex interaction Animal modeling an oligodendrogliopathy--multiple system atrophy Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease.Towards translational therapies for multiple system atrophy Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.The neuropathology, pathophysiology and genetics of multiple system atrophy.Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy.Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy Identification of synaptosomal proteins binding to monomeric and oligomeric α-synuclein.Characterization of kinases involved in the phosphorylation of aggregated α-synuclein.Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context.Treatment of cultured human astrocytes and vascular endothelial cells with protein kinase CK2 inhibitors induces early changes in cell shape and cytoskeleton.α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP.Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization.Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains.Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy.Transglutaminase activation in neurodegenerative diseases.Blood Plasma of Patients with Parkinson's Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity.Lipid dysfunction and pathogenesis of multiple system atrophy.Yeast unfolds the road map toward alpha-synuclein-induced cell death.Parkinson's disease dementia and potential therapeutic strategies.Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts.Interaction between pathogenic proteins in neurodegenerative disorders.The role of glia in α-synucleinopathies.Oligodendroglia and neurotrophic factors in neurodegeneration.Protein phosphorylation in neurodegeneration: friend or foe?Neuropathology of multiple system atrophy: new thoughts about pathogenesis.Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Investigational α-synuclein aggregation inhibitors: hope for Parkinson's disease.Oxidative stress promotes uptake, accumulation, and oligomerization of extracellular α-synuclein in oligodendrocytes.Tenuigenin attenuates α-synuclein-induced cytotoxicity by down-regulating polo-like kinase 3.Pramipexole reduces phosphorylation of α-synuclein at serine-129.Potassium depolarization and raised calcium induces α-synuclein aggregates.Loss of DJ-1 protein stability and cytoprotective function by Parkinson's disease-associated proline-158 deletion.SUMO-1 is associated with a subset of lysosomes in glial protein aggregate diseases.α-Synuclein potentiates interleukin-1β-induced CXCL10 expression in human A172 astrocytoma cells.

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Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.

http://www.wikidata.org/entity/Q39885727

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Alpha-synuclein aggregation an ...... ath in oligodendroglial cells.

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Alpha-synuclein aggregation an ...... eath in oligodendroglial cells

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Christiane Richter-Landsberg

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Christine L Kragh

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Fabia Febbraro

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Louise B Lund

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Omar El-Agnaf

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Wei-Ping Gai

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P2860

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies

Multiple system atrophy: cellular and molecular pathology.

p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy

The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

alpha-Synuclein locus triplication causes Parkinson's disease

Alpha-synuclein in Lewy bodies

Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases

Synucleins are a novel class of substrates for G protein-coupled receptor kinases

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10211-10222

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10.1074/JBC.M809671200

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19203998

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phosphorylation

oligodendrocyte

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2665075

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