A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation. - Wikidata - awgldk - TriplyDB

A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation.

A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation.

http://www.wikidata.org/entity/Q39887736

about

An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis Regulation of cellular iron metabolism RNA silencing of mitochondrial m-Nfs1 reduces Fe-S enzyme activity both in mitochondria and cytosol of mammalian cells Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster Threonine phosphorylation prevents promoter DNA binding of the Group B Streptococcus response regulator CovR.Protein degradation and iron homeostasis Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity.Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.New insights into ferritin synthesis and function highlight a link between iron homeostasis and oxidative stress in plants.Nitric oxide and frataxin: two players contributing to maintain cellular iron homeostasis.Living with iron (and oxygen): questions and answers about iron homeostasis.Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1.Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway Excess capacity of the iron regulatory protein system.The role of reactive oxygen and nitrogen species in cellular iron metabolism.Molecular control of vertebrate iron homeostasis by iron regulatory proteins Mammalian iron metabolism and its control by iron regulatory proteins Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling.Selective inhibition of the citrate-to-isocitrate reaction of cytosolic aconitase by phosphomimetic mutation of serine-711.Chlamydia trachomatis alters iron-regulatory protein-1 binding capacity and modulates cellular iron homeostasis in HeLa-229 cells.IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities.A synergistic role of IRP1 and FBXL5 proteins in coordinating iron metabolism during cell proliferation.Down-regulation of iron regulatory protein 1 activities and expression in superoxide dismutase 1 knock-out mice is not associated with alterations in iron metabolism.

P2860

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P2860

A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation.

http://www.wikidata.org/entity/Q39887736

description

2003 nî lūn-bûn

@nan

2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

2003年學術文章

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2003年學術文章

@zh-hant

name

A phosphomimetic mutation at S ...... to iron-dependent degradation.

@en

A phosphomimetic mutation at S ...... to iron-dependent degradation.

@nl

type

label

A phosphomimetic mutation at S ...... to iron-dependent degradation.

@en

A phosphomimetic mutation at S ...... to iron-dependent degradation.

@nl

prefLabel

A phosphomimetic mutation at S ...... to iron-dependent degradation.

@en

A phosphomimetic mutation at S ...... to iron-dependent degradation.

@nl

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P356

MCB.23.19.6973-6981.2003

P1433

Molecular and Cellular Biology

P1476

A phosphomimetic mutation at S ...... to iron-dependent degradation.

@en

P2093

Annie Caltagirone

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Carine Fillebeen

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Danielle Chahine

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Kostas Pantopoulos

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Phillip Segal

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P2860

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2

Iron regulatory proteins and the molecular control of mammalian iron metabolism

Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress

The iron-sulfur cluster of iron regulatory protein 1 modulates the accessibility of RNA binding and phosphorylation sites

Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome

Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding

Iron-sulfur clusters: nature's modular, multipurpose structures.

Novel role of phosphorylation in Fe-S cluster stability revealed by phosphomimetic mutations at Ser-138 of iron regulatory protein 1

Regulation of the iron regulatory proteins by reactive nitrogen and oxygen species.

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6973-6981

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scholarly article

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10.1128/MCB.23.19.6973-6981.2003

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193948

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