Altered integration of matrilin-3 into cartilage extracellular matrix in the absence of collagen IX. - Wikidata - awgldk - TriplyDB

Altered integration of matrilin-3 into cartilage extracellular matrix in the absence of collagen IX.

Altered integration of matrilin-3 into cartilage extracellular matrix in the absence of collagen IX.

http://www.wikidata.org/entity/Q39891469

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A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation.Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP Crystal structure of the N-terminal NC4 domain of collagen IX, a zinc binding member of the laminin-neurexin-sex hormone binding globulin (LNS) domain family The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen Identification of differentially expressed genes in the growth plate of broiler chickens with thiram-induced tibial dyschondroplasia.Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage.Differential gene expression of the intermediate and outer interzone layers of developing articular cartilage in murine embryos.Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders Elevated Levels of Cartilage Oligomeric Matrix Protein during In Vitro Cartilage Matrix Generation Decrease Collagen Fibril Diameter.NC4 Domain of cartilage-specific collagen IX inhibits complement directly due to attenuation of membrane attack formation and indirectly through binding and enhancing activity of complement inhibitors C4B-binding protein and factor H.Unique matrix structure in the rough endoplasmic reticulum cisternae of pseudoachondroplasia chondrocytes.Enhanced activity of transforming growth factor β1 (TGF-β1) bound to cartilage oligomeric matrix protein.β1 Integrins Mediate Attachment of Mesenchymal Stem Cells to Cartilage Lesions.Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation Role of proopiomelanocortin-derived peptides and their receptors in the osteoarticular system: from basic to translational research.Comparative proteomic analysis of normal and collagen IX null mouse cartilage reveals altered extracellular matrix composition and novel components of the collagen IX interactome.Anulus fibrosus tension inhibits degenerative structural changes in lamellar collagen.The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage The interaction of Thrombospondins with extracellular matrix proteins.Fell-Muir Lecture: Proteoglycans and more--from molecules to biology.Matrilin-3 chondrodysplasia mutations cause attenuated chondrogenesis, premature hypertrophy and aberrant response to TGF-β in chondroprogenitor cells Matrilin-3 induction of IL-1 receptor antagonist is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression.Inhibition of collagen XVI expression reduces glioma cell invasiveness.Structural and functional investigations of Matrilin-1 A-domains reveal insights into their role in cartilage ECM assembly.Matrilin-1 is essential for zebrafish development by facilitating collagen II secretion Proteolytic processing causes extensive heterogeneity of tissue matrilin forms.Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures.Structural and functional characterization of recombinant matrilin-3 A-domain and implications for human genetic bone diseases.Modification of the composition of articular cartilage collagen fibrils with increasing age.Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle-mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response.Fragmentation of proteins in cartilage treated with interleukin-1: specific cleavage of type IX collagen by matrix metalloproteinase 13 releases the NC4 domain.Recombinant Extracellular Matrix Protein fragments Support Human Embryonic Stem Cell Chondrogenesis.Effect of different running modes on the morphological, biochemical, and mechanical properties of articular cartilage.Extracellular Distribution of Collagen II and Perifibrillar Adapter Proteins in Healthy and Osteoarthritic Human Knee Joint Cartilage.Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin.Growth-related structural, biochemical, and mechanical properties of the functional bone-cartilage unit.Absence of collagen IX accelerates hypertrophic differentiation in the embryonic mouse spine through a disturbance of the Ihh-PTHrP feedback loop.MED and PSACH COMP mutations affect chondrogenesis in chicken limb bud micromass cultures.

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Altered integration of matrilin-3 into cartilage extracellular matrix in the absence of collagen IX.

http://www.wikidata.org/entity/Q39891469

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2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Altered integration of matrili ...... in the absence of collagen IX.

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Altered integration of matrili ...... in the absence of collagen IX.

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type

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Altered integration of matrili ...... in the absence of collagen IX.

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Altered integration of matrili ...... in the absence of collagen IX.

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prefLabel

Altered integration of matrili ...... in the absence of collagen IX.

@en

Altered integration of matrili ...... in the absence of collagen IX.

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MCB.25.23.10465-10478.2005

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Molecular and Cellular Biology

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Altered integration of matrili ...... in the absence of collagen IX.

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Bastian Budde

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Frank Zaucke

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Harald W A Ehlen

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Joni Ylöstalo

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Katrin Blumbach

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Leena Ala-Kokko

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Mats Paulsson

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Peter Bruckner

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Raimund Wagener

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Susanne Grässel

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P2860

Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX

Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias

Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene

A mutation in COL9A1 causes multiple epiphyseal dysplasia: further evidence for locus heterogeneity

Cartilage oligomeric matrix protein-deficient mice have normal skeletal development.

COL9A3: A third locus for multiple epiphyseal dysplasia.

Missense mutations in the beta strands of the single A-domain of matrilin-3 result in multiple epiphyseal dysplasia

Matrilin-3 mutations that cause chondrodysplasias interfere with protein trafficking while a mutation associated with hand osteoarthritis does not

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

An allele of COL9A2 associated with intervertebral disc disease

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extracellular matrix

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1291247

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