Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. - Wikidata - awgldk - TriplyDB

Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction.

Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction.

http://www.wikidata.org/entity/Q39895375

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The hedgehog receptor patched is involved in cholesterol transport A genetic screen in Drosophila for identifying novel components of the hedgehog signaling pathway.Suppressor of fused regulates Gli activity through a dual binding mechanism Differential range and activity of various forms of the Hedgehog protein Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened Hippi is essential for node cilia assembly and Sonic hedgehog signaling Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2.Extensive phosphorylation of Smoothened in Hedgehog pathway activation Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway In vivo analysis of compound activity and mechanism of action using epistasis in Drosophila.Model of the reception of hedgehog morphogen concentration gradient: comparison with an extended range of experimental data.Quantitative analysis of Hedgehog gradient formation using an inducible expression system.Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration.Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.Genetic and biochemical definition of the Hedgehog receptor.Rab23 plays a role in the pathophysiology of mesangial cells--a proteomic analysis.Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling.Mechanism and evolution of cytosolic Hedgehog signal transduction In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila.Role of lipid metabolism in smoothened derepression in hedgehog signaling.Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail.Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway.Regulation of Hedgehog signaling: a complex story.Ihog and Boi are essential for Hedgehog signaling in Drosophila.Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling.The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover.CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway.Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2 The Hedgehog signaling pathway--implications for drug targets in cancer and neurodegenerative disorders.Regulation of smoothened by Drosophila G-protein-coupled receptor kinases.The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation.Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila.Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer.Hedgehog pathway activation in human transitional cell carcinoma of the bladder Thirty-one flavors of Drosophila rab proteins.

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P2860

Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction.

http://www.wikidata.org/entity/Q39895375

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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name

Altered localization of Drosop ...... Hedgehog signal transduction.

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Altered localization of Drosop ...... Hedgehog signal transduction.

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type

label

Altered localization of Drosop ...... Hedgehog signal transduction.

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Altered localization of Drosop ...... Hedgehog signal transduction.

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Altered localization of Drosop ...... Hedgehog signal transduction.

@en

Altered localization of Drosop ...... Hedgehog signal transduction.

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Genes & Development

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Altered localization of Drosop ...... Hedgehog signal transduction.

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Alan Jian Zhu

http://www.w3.org/2001/XMLSchema#string

Kaye Suyama

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Limin Zheng

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Matthew P Scott

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P2860

Activating Smoothened mutations in sporadic basal-cell carcinoma

Mutations in human dynamin block an intermediate stage in coated vesicle formation

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

Hedgehog signaling in animal development: paradigms and principles

Sonic hedgehog induces the segregation of patched and smoothened in endosomes

Patched acts catalytically to suppress the activity of Smoothened

Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway

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1240-1252

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10.1101/GAD.1080803

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17

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