Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells. - Wikidata - awgldk - TriplyDB

Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells.

Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells.

http://www.wikidata.org/entity/Q39904227

about

Human NKG2D-ligands: cell biology strategies to ensure immune recognition NKG2D ligands as therapeutic targets IFN-γ Rα is a key determinant of CD8+ T cell-mediated tumor elimination or tumor escape and relapse in FVB mouse Glycosyl-Phosphatidyl-Inositol (GPI)-Anchors and Metalloproteases: Their Roles in the Regulation of Exosome Composition and NKG2D-Mediated Immune Recognition Interleukin 10 decreases MICA expression on melanoma cell surface.Oncogenic stress sensed by the immune system: role of natural killer cell receptors NK cells: immune cross-talk and therapeutic implications.Natural killer (NK) cell profiles in blood and tumour in women with large and locally advanced breast cancer (LLABC) and their contribution to a pathological complete response (PCR) in the tumour following neoadjuvant chemotherapy (NAC): differentia STAT1: A Novel Target of miR-150 and miR-223 Is Involved in the Proliferation of HTLV-I-Transformed and ATL Cells.Natural killer cell-produced IFN-γ and TNF-α induce target cell cytolysis through up-regulation of ICAM-1.An integrated view of the regulation of NKG2D ligands.Testing the theory of immune selection in cancers that break the rules of transplantation.Effect of NKG2D ligand expression on host immune responses Immune-related biomarkers for diagnosis/prognosis and therapy monitoring of cutaneous melanoma.Immunotherapy of MHC class I-deficient tumors.Mechanisms of tumor and viral immune escape from natural killer cell-mediated surveillance.NK cell recognition and killing of melanoma cells is controlled by multiple activating receptor-ligand interactions.Manipulation of NKG2D ligands by cytomegaloviruses: impact on innate and adaptive immune response.Regulation of self-ligands for activating natural killer cell receptors.NKG2D signaling in cancer immunosurveillance.Melanoma-associated fibroblasts decrease tumor cell susceptibility to NK cell-mediated killing through matrix-metalloproteinases secretion Critical role of the NKG2D receptor for NK cell-mediated control and immune escape of B-cell lymphoma.The Hedgehog inhibitor cyclopamine impairs the benefits of immunotherapy with activated T and NK lymphocytes derived from patients with advanced cancer.A dual function of NKG2D ligands in NK-cell activation.Melanoma cells become resistant to NK-cell-mediated killing when exposed to NK-cell numbers compatible with NK-cell infiltration in the tumor.Histamine reduces susceptibility to natural killer cells via down-regulation of NKG2D ligands on human monocytic leukaemia THP-1 cells.Role of the MICA polymorphism in systemic lupus erythematosus.Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors.In vivo major histocompatibility complex class I (MHCI) expression on MHCIlow tumor cells is regulated by gammadelta T and NK cells during the early steps of tumor growth.MicroRNA-519a-3p mediates apoptosis resistance in breast cancer cells and their escape from recognition by natural killer cells New twist on the regulation of NKG2D ligand expression.Tumor suppressors control ULBP2, an innate surface ligand of the lymphocyte immune receptor NKG2D.Modulation of antitumour immune responses by intratumoural Stat1 expression.Secretory pathways generating immunosuppressive NKG2D ligands: New targets for therapeutic intervention.Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8+ T Cells and Histone Acetyltransferases.Impaired NK cell recognition of vemurafenib-treated melanoma cells is overcome by simultaneous application of histone deacetylase inhibitors.Functions of NKG2D in CD8+ T cells: an opportunity for immunotherapy.Intragenic transcriptional interference regulates the human immune ligand MICA.The Paradoxical Role of NKG2D in Cancer Immunity

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Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells.

http://www.wikidata.org/entity/Q39904227

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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name

Interferon-gamma down-regulate ...... anoma by natural killer cells.

@en

Interferon-gamma down-regulate ...... anoma by natural killer cells.

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type

label

Interferon-gamma down-regulate ...... anoma by natural killer cells.

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Interferon-gamma down-regulate ...... anoma by natural killer cells.

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prefLabel

Interferon-gamma down-regulate ...... anoma by natural killer cells.

@en

Interferon-gamma down-regulate ...... anoma by natural killer cells.

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International Journal of Cancer

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Interferon-gamma down-regulate ...... anoma by natural killer cells.

@en

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Adelheid Cerwenka

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Annette Paschen

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Daria Vokhminova

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Iris Moll

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Nicole Schwinn

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Sandra Striegel

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Sonja Textor

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P2860

Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor

Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans.

Immune selection of hot-spot beta 2-microglobulin gene mutations, HLA-A2 allospecificity loss, and antigen-processing machinery component down-regulation in melanoma cells derived from recurrent metastases following immunotherapy

Intracellular retention of the NKG2D ligand MHC class I chain-related gene A in human melanomas confers immune privilege and prevents NK cell-mediated cytotoxicity.

Promoter region architecture and transcriptional regulation of the genes for the MHC class I-related chain A and B ligands of NKG2D.

IFN-dependent down-regulation of the NKG2D ligand H60 on tumors.

Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo.

Intracellular retention of the MHC class I-related chain B ligand of NKG2D by the human cytomegalovirus UL16 glycoprotein.

Characterization of human T cells that regulate neutrophilic skin inflammation.

Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients.

P304

1594-1604

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scholarly article

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10.1002/IJC.24098

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7

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124

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Dirk Schadendorf

Alexander Steinle

Jochen Tuettenberg

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2009-04-01T00:00:00Z

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229554850

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19089914

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