Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression.
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Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular DamageEndoplasmic reticulum stress and Nox-mediated reactive oxygen species signaling in the peripheral vasculature: potential role in hypertensionThinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signalingCommunity structure analysis of transcriptional networks reveals distinct molecular pathways for early- and late-onset temporal lobe epilepsy with childhood febrile seizuresGlobal quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex.UPR-induced resistance to etoposide is downstream of PERK and independent of changes in topoisomerase IIα levelsPhosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsyReactive oxygen and nitrogen species in steatotic hepatocytes: a molecular perspective on the pathophysiology of ischemia-reperfusion injury in the fatty liver.PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease.Regulation of xCT expression and system x (c) (-) function in neuronal cells.Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response.The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.Dysregulation of system xc(-) expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 miceATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson's diseaseUnfolded Protein Response (UPR) is activated during normal lens developmentDeletion of the eIF2α Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease.PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment.Expression of xCT and activity of system xc(-) are regulated by NRF2 in human breast cancer cells in response to oxidative stress.Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer's DiseaseIntegrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism.Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity.Stromal interaction molecule 1 (STIM1) is involved in the regulation of mitochondrial shape and bioenergetics and plays a role in oxidative stress.Interleukin 1β Regulation of the System xc- Substrate-specific Subunit, xCT, in Primary Mouse Astrocytes Involves the RNA-binding Protein HuROsteoporosis regulation by salubrinal through eIF2α mediated differentiation of osteoclast and osteoblast.PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.Glutamate transporters in brain ischemia: to modulate or not?A novel transcription mechanism activated by ethanol: induction of Slc7a11 gene expression via inhibition of the DNA-binding activity of transcriptional repressor octamer-binding transcription factor 1 (OCT-1)Modulation of 5-lipoxygenase in proteotoxicity and Alzheimer's disease.Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchangerGeneral control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in miceThe eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.EAAT3 promotes amino acid transport and proliferation of porcine intestinal epithelial cells.Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis.Mitochondrial function and energy metabolism in neuronal HT22 cells resistant to oxidative stress.Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway.Roles of eIF2α kinases in the pathogenesis of Alzheimer's disease.Molecular biomarkers of lung carcinoma.Redox regulation in stem-like cancer cells by CD44 variant isoforms.Main path and byways: non-vesicular glutamate release by system xc(-) as an important modifier of glutamatergic neurotransmission.
P2860
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P2860
Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Basal levels of eIF2alpha phos ...... ating ATF4 and xCT expression.
@en
Basal levels of eIF2alpha phos ...... ating ATF4 and xCT expression.
@nl
type
label
Basal levels of eIF2alpha phos ...... ating ATF4 and xCT expression.
@en
Basal levels of eIF2alpha phos ...... ating ATF4 and xCT expression.
@nl
prefLabel
Basal levels of eIF2alpha phos ...... ating ATF4 and xCT expression.
@en
Basal levels of eIF2alpha phos ...... ating ATF4 and xCT expression.
@nl
P2860
P356
P1476
Basal levels of eIF2alpha phos ...... ating ATF4 and xCT expression.
@en
P2093
Jan Lewerenz
Pamela Maher
P2860
P304
P356
10.1074/JBC.M807325200
P407
P577
2008-11-18T00:00:00Z