Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function.
about
Kisspeptin signaling in the brainThe second intracellular loop of the human cannabinoid CB2 receptor governs G protein coupling in coordination with the carboxyl terminal domainRegulation of GPR54 signaling by GRK2 and {beta}-arrestinNovel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner.Phosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy.The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism.International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin receptor nomenclature, distribution, and function.KISS1R signals independently of Gαq/11 and triggers LH secretion via the β-arrestin pathway in the male mouse.Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome.Structural determinants in the second intracellular loop of the human cannabinoid CB1 receptor mediate selective coupling to G(s) and G(i)Disease-causing mutation in PKR2 receptor reveals a critical role of positive charges in the second intracellular loop for G-protein coupling and receptor trafficking.Structural basis of G protein-coupled receptor-G protein interactions.G protein-coupled receptors involved in GnRH regulation: molecular insights from human disease.Mutagenesis and analysis of genetic mutations in the GC-rich KISS1 receptor sequence identified in humans with reproductive disorders.GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH SecretionConformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective.Linking receptor activation to changes in Sw I and II of Gα proteins.Haploinsufficiency in the prometastasis Kiss1 receptor Gpr54 delays breast tumor initiation, progression, and lung metastasisDynamic kisspeptin receptor trafficking modulates kisspeptin-mediated calcium signalingTACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients.Cannabinoid receptor interacting protein (CRIP1a) attenuates CB1R signaling in neuronal cellsModeling the possible conformations of the extracellular loops in G-protein-coupled receptors.Conformational Change in the Ligand-Binding Pocket via a KISS1R Mutation (P147L) Leads to Isolated Gonadotropin-Releasing Hormone Deficiency.
P2860
Q28259280-6783A565-07D5-4304-989D-CF4573DB0A83Q28487693-799F0D02-A708-4669-8848-009AC34A2B28Q33642051-C7C1EDB0-07BE-4395-B2A7-949EEAB6E6D3Q33669652-DC49BE5D-DE47-4162-8D50-094718491CBEQ33707710-1ED0701D-50D1-45EE-A2EC-39933F537FE8Q33714824-325BAD02-9BF6-42F5-92F5-BB9C09E7973DQ33830319-C30E4BF6-7C73-4374-8C44-57FB43C6A241Q34149940-DA11AEB6-878A-4BA2-BCFC-21160EF7B635Q34343082-C88CC4EB-2949-46A6-8661-4FB879D08889Q34411579-F2C0EE6C-23EC-4FC9-AE3A-C3160212A33DQ34442426-E6175CB5-E96F-40DC-B6B6-10AFDBCB8F1DQ34947403-99B185F0-B2DD-46F7-8203-3D8ABB91CEB8Q35015644-28015358-BA16-4711-AC91-22817F80BDF9Q35256585-04CEFCB9-F2BC-450B-A694-6B3F106FB29EQ35552981-9717349D-9FF7-4FB5-9CBB-D09E16330171Q36064423-31CB45FF-6C5C-4BE8-8F72-798EE4F0D5CDQ36941174-70C78E03-A7D2-41E2-8F1A-696B6516B05DQ37053797-BC410E57-C037-49D2-BF08-97F7FE1506A2Q37105376-924B7E11-4B32-426D-A89C-18610245AB12Q37417683-96690AD0-CD4A-4907-8B81-39E9ABD99324Q37657090-B8C1D7B6-7EB3-4C18-BA9F-B05CC3816389Q38935678-CDB93E4F-0111-49E0-95FC-AE3195DAD1D0Q42951624-11F7DD14-3386-436C-A06F-4C0C72E1A135Q52407086-788741D4-091C-4E61-B14A-4676EA4A1D7C
P2860
Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Disease-causing mutation in GP ...... ein-coupled receptor function.
@en
Disease-causing mutation in GP ...... ein-coupled receptor function.
@nl
type
label
Disease-causing mutation in GP ...... ein-coupled receptor function.
@en
Disease-causing mutation in GP ...... ein-coupled receptor function.
@nl
prefLabel
Disease-causing mutation in GP ...... ein-coupled receptor function.
@en
Disease-causing mutation in GP ...... ein-coupled receptor function.
@nl
P2093
P2860
P356
P1476
Disease-causing mutation in GP ...... ein-coupled receptor function.
@en
P2093
Andrew J Mhyre
Chris Hague
David B Feller
Jennifer L Wacker
Jill B Jensen
John S Lyssand
Mia C Defino
Xiao-Bo Tang
Yuree Namkung
P2860
P304
31068-31078
P356
10.1074/JBC.M805251200
P407
P577
2008-09-04T00:00:00Z