Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis. - Wikidata - awgldk - TriplyDB

Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis.

Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis.

http://www.wikidata.org/entity/Q39945691

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Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor-positive breast cancer The Obesity-Breast Cancer Conundrum: An Analysis of the Issues Understanding the Key to Targeting the IGF Axis in Cancer: A Biomarker Assessment Crosstalk of the Insulin-Like Growth Factor Receptor with the Wnt Signaling Pathway in Breast Cancer Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancer Lipid biology of breast cancer Minireview: Inflammation: an instigator of more aggressive estrogen receptor (ER) positive breast cancers Integrated genomic analyses of ovarian carcinoma Molecular Pathways: Clinical Applications and Future Direction of Insulin-like Growth Factor-1 Receptor Pathway Blockade Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells Gene expression-based chemical genomics identifies potential therapeutic drugs in hepatocellular carcinoma Altered expression of insulin receptor isoforms in breast cancer Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features Epidemiological and molecular mechanisms aspects linking obesity and cancer.Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse.HOXA1 drives melanoma tumor growth and metastasis and elicits an invasion gene expression signature that prognosticates clinical outcome.Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605.IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients.COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis.ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism.Building prognostic models for breast cancer patients using clinical variables and hundreds of gene expression signatures.Relationship of mammographic density and gene expression: analysis of normal breast tissue surrounding breast cancer.Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer.Cross-talk between HER2 and MED1 regulates tamoxifen resistance of human breast cancer cells.Clinical potential of novel therapeutic targets in breast cancer: CDK4/6, Src, JAK/STAT, PARP, HDAC, and PI3K/AKT/mTOR pathways.A genomic signature approach to rescue ΔF508-cystic fibrosis transmembrane conductance regulator biosynthesis and function.Can we unlock the potential of IGF-1R inhibition in cancer therapy?Growth hormone potentiates 17β-estradiol-dependent breast cancer cell proliferation independently of IGF-I receptor signaling.Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer.CCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland.Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling Prognostic and predictive value of Phospho-p44/42 and pAKT in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy.Molecular characterisation of cell line models for triple-negative breast cancers.Parity-related molecular signatures and breast cancer subtypes by estrogen receptor status Modulation of insulin/IGFs pathways by sirtuin-7 inhibition in drug-induced chemoreistance Distinct luminal-type mammary carcinomas arise from orthotopic Trp53-null mammary transplantation of juvenile versus adult mice.High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy

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Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis.

http://www.wikidata.org/entity/Q39945691

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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name

Insulin-like growth factor-I a ...... poor breast cancer prognosis.

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Insulin-like growth factor-I a ...... poor breast cancer prognosis.

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type

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Insulin-like growth factor-I a ...... poor breast cancer prognosis.

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Insulin-like growth factor-I a ...... poor breast cancer prognosis.

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prefLabel

Insulin-like growth factor-I a ...... poor breast cancer prognosis.

@en

Insulin-like growth factor-I a ...... poor breast cancer prognosis.

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JCO.2007.13.4429

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Journal of Clinical Oncology

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Insulin-like growth factor-I a ...... poor breast cancer prognosis.

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Adrian V Lee

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Angelo Casa

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Anna Tsimelzon

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Chad J Creighton

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Charles Kent Osborne

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Shixia Huang

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Susan G Hilsenbeck

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ZaWaunyka Lazard

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P2860

Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds

Cluster analysis and display of genome-wide expression patterns

The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer.

Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection

Gene expression profiling predicts clinical outcome of breast cancer

A gene-expression signature as a predictor of survival in breast cancer

Repeated observation of breast tumor subtypes in independent gene expression data sets

Java Treeview--extensible visualization of microarray data

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

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