Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity.
about
Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasisMultidomain integration in the structure of the HNF-4α nuclear receptor complexDirect methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genesPhenobarbital Meets Phosphorylation of Nuclear ReceptorsBile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway.Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modificationsDisruption of the murine protein kinase Cbeta gene promotes gallstone formation and alters biliary lipid and hepatic cholesterol metabolismCytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis.Scoparone potentiates transactivation of the bile salt export pump gene and this effect is enhanced by cytochrome P450 metabolism but abolished by a PKC inhibitor.Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease.Nuclear receptors and the Warburg effect in cancer.General molecular biology and architecture of nuclear receptors.p38 MAP Kinase Links CAR Activation and Inactivation in the Nucleus via Phosphorylation at Threonine 38.Bile acids as regulatory molecules.Soaping up type 2 diabetes with bile acids?: the link between glucose and bile acid metabolism in humans tightens: quality matters!FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states.Modulation of Hepatic Protein Kinase Cβ Expression in Metabolic Adaptation to a Lithogenic DietControl of nuclear receptor activities in metabolism by post-translational modifications.Characterizing ligands for farnesoid X receptor--available in vitro test systems for farnesoid X receptor modulator development.Posttranslational Modifications of Lipid-Activated Nuclear Receptors: Focus on Metabolism.PKCβ: Expanding role in hepatic adaptation of cholesterol homeostasis to dietary fat/cholesterol.Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes.Phosphorylation of Farnesoid X Receptor at Serine 154 Links Ligand Activation With Degradation.Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptorsBile acids in glucose metabolism in health and disease.H2 S inhibits apo(a) expression and secretion through PKCα/FXR and Akt/HNF4α pathways in HepG2 cells.Bile acids as global regulators of hepatic nutrient metabolism
P2860
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P2860
Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Phosphorylation of farnesoid X ...... its transcriptional activity.
@en
Phosphorylation of farnesoid X ...... its transcriptional activity.
@nl
type
label
Phosphorylation of farnesoid X ...... its transcriptional activity.
@en
Phosphorylation of farnesoid X ...... its transcriptional activity.
@nl
prefLabel
Phosphorylation of farnesoid X ...... its transcriptional activity.
@en
Phosphorylation of farnesoid X ...... its transcriptional activity.
@nl
P2093
P356
P1476
Phosphorylation of farnesoid X ...... its transcriptional activity.
@en
P2093
Alexis Aquilina
Audrey Sirvent
Dean W Hum
Jean-Charles Fruchart
Raphaël Darteil
Romain Gineste
Stéphane Helleboid
P304
P356
10.1210/ME.2008-0092
P577
2008-08-28T00:00:00Z