Palladacycles catalyse the oxidation of critical thiols of the mitochondrial membrane proteins and lead to mitochondrial permeabilization and cytochrome c release associated with apoptosis.

Palladacycles catalyse the oxidation of critical thiols of the mitochondrial membrane proteins and lead to mitochondrial permeabilization and cytochrome c release associated with apoptosis.

Item
http://www.wikidata.org/entity/Q39946589
In vitro and in vivo activity of a palladacycle complex on Leishmania (Leishmania) amazonensisA cyclopalladated complex interacts with mitochondrial membrane thiol-groups and induces the apoptotic intrinsic pathway in murine and cisplatin-resistant human tumor cells.In vitro and in vivo trypanocidal effects of the cyclopalladated compound 7a, a drug candidate for treatment of Chagas' disease.C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma.Effect of garlic-derived organosulfur compounds on mitochondrial function and integrity in isolated mouse liver mitochondria.Synergistic antitumour activity of sorafenib in combination with tetrandrine is mediated by reactive oxygen species (ROS)/Akt signaling.Specific effects of reactive thiol drugs on mitochondrial bioenergetics.Cytochrome C and Caspase-3/7 are Involved in Mycophenolic Acid- Induced Apoptosis in Genetically Engineered PC12 Neuronal Cells Expressing the p53 gene.Organopalladium compound 7b targets mitochondrial thiols and induces caspase-dependent apoptosis in human myeloid leukemia cells.Alteration in mitochondrial thiol enhances calcium ion dependent membrane permeability transition and dysfunction in vitro: a cross-talk between mtThiol, Ca(2+), and ROS.Leishmanicidal and Immunomodulatory Activities of the Palladacycle Complex DPPE 1.1, a Potential Candidate for Treatment of Cutaneous Leishmaniasis.
P2860

Palladacycles catalyse the oxidation of critical thiols of the mitochondrial membrane proteins and lead to mitochondrial permeabilization and cytochrome c release associated with apoptosis.

Item
http://www.wikidata.org/entity/Q39946589
description
2009 nî lūn-bûn
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Palladacycles catalyse the oxi ...... ase associated with apoptosis.
@en
Palladacycles catalyse the oxi ...... ase associated with apoptosis.
@nl
type
label
Palladacycles catalyse the oxi ...... ase associated with apoptosis.
@en
Palladacycles catalyse the oxi ...... ase associated with apoptosis.
@nl
prefLabel
Palladacycles catalyse the oxi ...... ase associated with apoptosis.
@en
Palladacycles catalyse the oxi ...... ase associated with apoptosis.
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P356
P1433
P1476
Palladacycles catalyse the oxi ...... ease associated with apoptosis
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921